The host perinuclear region is the host cytoplasmic region just around the host nucleus. Note: This location is defined for viral proteins that appear in the perinuclear region of infected host cells
[Picornain 3C-like protease]: Thiol protease that cleaves the RNA1 and RNA2 polyproteins. {Experimental EvidencePubMed:16453750, Experimental EvidencePubMed:16789216, Experimental EvidencePubMed:8811039}. [Viral genome-linked protein]: Plays a role in RNA replication. It is covalently linked to the 5'terminus of both viral single-stranded RNA1 and RNA2 molecules. {Experimental EvidencePubMed:11883002, Experimental EvidencePubMed:16453534}. [Protease cofactor]: Down-regulates the RNA1 polyprotein processing and enhances trans-cleavage of RNA2 polyproteins (PubMed:1413528). The protease cofactor and the putative helicase seem to target the replication complexes to ER membranes. Their physical association causes the membrane rearrangement of host ER that may result in formation of the small membranous vesicles that are the site of viral RNA synthesis (PubMed:12021362). {Experimental EvidencePubMed:12021362, Experimental EvidencePubMed:1413528}. [Putative helicase]: The protease cofactor and the putative helicase seem to target the replication complexes to ER membranes. Their physical association causes the membrane rearrangement of host ER that may result in formation of the small membranous vesicles that are the site of viral RNA synthesis. {Experimental EvidencePubMed:12021362}. [RNA-directed RNA polymerase]: Replicates the viral genome. {ECO:0000305|PubMed:1431806}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory