NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Interferon-induced GTP-binding protein Mx1 - Mus musculus - NucEnvDB

Interferon-induced GTP-binding protein Mx1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Interferon-induced GTP-binding protein Mx1
Accession Code	P09922
Gene	Mx1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	No
Sequence (Length: 631)
MDSVNNLCRHYEEKVRPCIDLIDTLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLRKLKEGEEWRGKVSYDDIEVELSDPSEVEEAINKGQNFIAGVGLGISDKLISL DVSSPNVPDLTLIDLPGITRVAVGNQPADIGRQIKRLIKTYIQKQETINLVVVPSNVDIATTEALSMAQEVDPEGDRTIGVLTKPDLVDRGAEGKVLDVMRNLVYPLKKGYMIVKCRGQQDIQEQLSLTE AFQKEQVFFKDHSYFSILLEDGKATVPCLAERLTEELTSHICKSLPLLEDQINSSHQSASEELQKYGADIPEDDRTRMSFLVNKISAFNRNIMNLIQAQETVSEGDSRLFTKLRNEFLAWDDHIEEYFKK DSPEVQSKMKEFENQYRGRELPGFVDYKAFESIIKKRVKALEESAVNMLRRVTKMVQTAFVKILSNDFGDFLNLCCTAKSKIKEIRLNQEKEAENLIRLHFQMEQIVYCQDQVYKETLKTIREKEAEKEK TKALINPATFQNNSQFPQKGLTTTEMTQHLKAYYQECRRNIGRQIPLIIQYFILKTFGEEIEKMMLQLLQDTSKCSWFLEEQSDTREKKKFLKRRLLRLDEARQKLAKFSD

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:21859714}. Nucleus {Experimental EvidencePubMed:21859714}. Endoplasmic reticulum membrane {ECO:0000250\|UniProtKB:P20591}; Peripheral membrane protein {ECO:0000250\|UniProtKB:P20591}; Cytoplasmic side {ECO:0000250\|UniProtKB:P20591}. Cytoplasm, perinuclear region {ECO:0000250\|UniProtKB:P20591}. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region. {ECO:0000250\|UniProtKB:P20591}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:P20591}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Endoplasmic Reticulum Membrane (GO:0005789) Membrane (GO:0016020) Microtubule (GO:0005874) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV), influenza B virus (IBV) and Thogoto virus (THOV). Inhibits FLUAV by interfering with the process of primary transcription, probably by affecting the viral polymerase function. {Experimental EvidencePubMed:17652381, Experimental EvidencePubMed:21651940}.
Assigned Ontology terms

Biological Process	Defense Response To Virus (GO:0051607) Innate Immune Response (GO:0045087) Response To Virus (GO:0009615)
Molecular Function	GTP Binding (GO:0005525) GTPase Activity (GO:0003924) Microtubule Binding (GO:0008017)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
Q6P1J9	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)	EBI-20726660	0.35

Cross-References

Database	Links
UNIPROT	P09922
Pfam	PF01031 PF00350 PF02212
PROSITE	PS00410 PS51718 PS51388

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