NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Trafficking protein particle complex subunit 2B - Homo sapiens - NucEnvDB

Trafficking protein particle complex subunit 2B (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Trafficking protein particle complex subunit 2B
Accession Code	P0DI82
Gene	TRAPPC2B
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 140)
MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKV QFLGKKHLLS

Subcellular Location

Description
Nucleus {By SimilarityUniProtKB:P0DI81}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:11134351}. Endoplasmic reticulum-Golgi intermediate compartment {By SimilarityUniProtKB:P0DI81}. Cytoplasm {By SimilarityUniProtKB:P0DI81}. Note=Localized in perinuclear granular structures. {By SimilarityUniProtKB:P0DI81}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Endoplasmic Reticulum (GO:0005783) Endoplasmic Reticulum-Golgi Intermediate Compartment (GO:0005793) Intracellular Membrane-Bounded Organelle (GO:0043231) Nuclear Outer Membrane (GO:0005640) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) TRAPP Complex (GO:0030008) TRAPPII Protein Complex (GO:1990071) TRAPPIII Protein Complex (GO:1990072)

Biology & Function

Description
Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi. {Experimental EvidencePubMed:11134351}.
Assigned Ontology terms

Biological Process	COPII Vesicle Coating (GO:0048208) Endoplasmic Reticulum To Golgi Vesicle-Mediated Transport (GO:0006888) Positive Regulation Of Gene Expression (GO:0010628) Vesicle Coating (GO:0006901) Vesicle Tethering (GO:0099022)
Molecular Function	Transcription Corepressor Binding (GO:0001222) Transcription Regulator Inhibitor Activity (GO:0140416)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
A0A286YCX6	Trafficking protein particle complex 8	EBI-11119288	0.35
O43493	Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2)	EBI-16800265	0.27

Cross-References

Database	Links
UNIPROT	P0DI82 A6NEG0 O14582 Q9HD16
Pfam	PF04628
DisGeNET	6399

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