NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

E3 ubiquitin-protein ligase RNF43 - Xenopus tropicalis - NucEnvDB

E3 ubiquitin-protein ligase RNF43 (Xenopus tropicalis)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	E3 ubiquitin-protein ligase RNF43
Accession Code	P0DPR2
Gene	rnf43
Organism	Xenopus tropicalis \| Tropical clawed frog (Taxonomy: 8364)
Part of Reference Proteome?	Yes
Sequence (Length: 689)
MNRARLQLASLWLLLTVTLQAVASAMGTTEREMDVKALIRVTPLQAEESGGVGQGNLTLEGLFARVAEISPAEGRLLQFHPLSLCNTSEDDQTKPGFISIVKLETPDRDTQPCLSLANKARLAGERGAHA VLFDITNDRGALQQLQQPAGINQPVVLIWGPDAEKLMDVVNKNKEALVKIEVQEQPKWLHHDIWILLTVAGTVMFFVLYAVARLLCRQPPPQDSIQQQTLLAISRLGTRRYQQRMLKDQRASGGWVETAS TSSSVPVCAICLEEFTDGQELRILPCCHEYHLGCVDPWLRQNHTCPLCMYDILDSGTPPRPLAHRAPSQTQLWGRYPGSARLMSHLPPHGTPMVFPTPNNSLFLPRAPYYLDHTHHWQMPEQMAMQMRTH RRGAEGTRELGISPGCQDSSGYLPDDPGSDSSSGPCHGSSSENCTDISLHCLHGTSSSSVHSSQSNQEDSSPPALASYLLPQGELPALNPLLSTQASYASHVHFHQHRHHHYRRNQPSMSHSHPHRSKRR TKVSRADPSYYREHRHTTGANGELRSLMVRREPRPSCSRTCFDPRTNREHPRHQQSMPQAASVVQGSSEPDVATSLRGSRTDPPSRTYRKKKSSAPSHLPLLYSPRHCHPANSVQMSESSHPRWAEEVRL LHSRVNSHRENTAMMHLYHPPHHNQGATEEIEAVCEHAV

Subcellular Location

Description
Cell membrane {By SimilarityUniProtKB:Q68DV7}; Single-pass type I membrane protein {By SimilarityUniProtKB:Q68DV7}. Endoplasmic reticulum membrane {By SimilarityUniProtKB:Q68DV7}; Single- pass type I membrane protein {By SimilarityUniProtKB:Q68DV7}. Nucleus envelope {By SimilarityUniProtKB:Q68DV7}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Endoplasmic Reticulum Membrane (GO:0005789) Nuclear Envelope (GO:0005635)

Biology & Function

Description
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (By similarity). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (PubMed:29769720). {By SimilarityUniProtKB:Q68DV7, Experimental EvidencePubMed:29769720}.
Assigned Ontology terms

Biological Process	Ubiquitin-Dependent Protein Catabolic Process (GO:0006511) Wnt Receptor Catabolic Process (GO:0038018) Wnt Signaling Pathway (GO:0016055)
Molecular Function	Frizzled Binding (GO:0005109) Metal Ion Binding (GO:0046872) Ubiquitin Protein Ligase Activity (GO:0061630)

Cross-References

Database	Links
UNIPROT	P0DPR2
Pfam	PF13639 PF18212
PROSITE	PS50089

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