NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Oxysterol-binding protein 1 - Oryctolagus cuniculus - NucEnvDB

Oxysterol-binding protein 1 (Oryctolagus cuniculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Oxysterol-binding protein 1
Accession Code	P16258
Gene	OSBP
Organism	Oryctolagus cuniculus \| Rabbit (Taxonomy: 9986)
Part of Reference Proteome?	Yes
Sequence (Length: 809)
MAATELRGVVGPGPAAIAAPGGGGAGPPVVGGGGGGRGDAGPGSGAASGTVAAAAAGGQGPGAGGVAAAAGPAPTPPAGGSGSSGTGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRH TCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQV NERATLFRITSNAMINACRDFLVLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPAHTSGSAGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDI SLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCE QVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDE KMDCFKVQPVSGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWEGGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDP VTKELTHIYRGEYWECKEKQDWNSCPDIF

Subcellular Location

Description
Cytoplasm, cytosol {By SimilarityUniProtKB:P22059}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P22059}. Golgi apparatus membrane {By SimilarityUniProtKB:P22059}; Peripheral membrane protein {By SimilarityUniProtKB:P22059}. Endoplasmic reticulum membrane {By SimilarityUniProtKB:P22059}; Peripheral membrane protein {By SimilarityUniProtKB:P22059}. Note=Predominantly cytosolic. {By SimilarityUniProtKB:P22059}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:P22059}
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Endoplasmic Reticulum Membrane (GO:0005789) Golgi Membrane (GO:0000139) Perinuclear Region Of Cytoplasm (GO:0048471) Trans-Golgi Network (GO:0005802)

Biology & Function

Description
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:18165705). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (By similarity). Regulates cholesterol efflux by decreasing ABCA1 stability (By similarity). {By SimilarityUniProtKB:P22059, Experimental EvidencePubMed:18165705}.
Assigned Ontology terms

Biological Process	Intracellular Cholesterol Transport (GO:0032367) Sterol Transport (GO:0015918)
Molecular Function	Cholesterol Binding (GO:0015485) Phosphatidylinositol-4-Phosphate Binding (GO:0070273) Sterol Transfer Activity (GO:0120015)

Cross-References

Database	Links
UNIPROT	P16258
Pfam	PF01237 PF00169
PROSITE	PS01013 PS50003

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