National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Deoxyribonuclease-1 |
| Accession Code | P24855 |
| Gene | DNASE1 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 282) |
Structure Viewer (PDB: 4AWN) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). {By SimilarityUniProtKB:P00639, By SimilarityUniProtKB:P21704, By SimilarityUniProtKB:P49183, Experimental EvidencePubMed:11241278, Experimental EvidencePubMed:2251263, Experimental EvidencePubMed:2277032}. | Assigned Ontology terms |
Description |
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|---|---|
| Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {Experimental EvidencePubMed:11479590, Experimental EvidencePubMed:20439745}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Neutrophil extracellular traps (NETs) are impaired in patients suffering from SLE (PubMed:20439745). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:20439745). {Experimental EvidencePubMed:20439745}. | Database Associations |
| OMIM | 125505 152700 |
| DisGeNET | 1773 |
Database | Links |
| UNIPROT | P24855 B4DV35 Q14UU9 Q14UV0 |
| PDB | 4AWN |
| Pfam | PF03372 |
| PROSITE | PS00919 PS00918 |
| OMIM | 125505 152700 |
| DisGeNET | 1773 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory