NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase - Oryctolagus cuniculus - NucEnvDB

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

Protein Information
Protein Name	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Accession Code	P27115
Gene	MGAT1
Organism	Oryctolagus cuniculus \| Rabbit (Taxonomy: 9986)
Part of Reference Proteome?	Yes
Sequence (Length: 447)
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPVPSRLPSDNALDDDPASLTREVIRLAQDAEVELERQRGLLQQIREHHA LWSQRWKVPTAAPPAQPHVPVTPPPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQVIASYGSA VTHIRQPDLSNIAVQPDHRKFQGYYKIARHYRWALGQIFHNFNYPAAVVVEDDLEVAPDFFEYFQATYPLLKADPSLWCV SAWNDNGKEQMVDSSKPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRKGRACVRPEISRTMTFGRKG VSHGQFFDQHLKFIKLNQQFVPFTQLDLSYLQQEAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFA KALGVMDDLKSGVPRAGYRGIVTFLFRGRRVHLAPPQTWDGYDPSWT

Structure Viewer (PDB: 2AM4)

Description
Golgi apparatus membrane {By SimilarityUniProtKB:P26572}; Single-pass type II membrane protein {By SimilarityUniProtKB:P26572}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P26572}. Note=Co-localizes with BRI3 at the perinuclear region. {By SimilarityUniProtKB:P26572}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Golgi Medial Cisterna (GO:0005797) Golgi Membrane (GO:0000139) Perinuclear Region Of Cytoplasm (GO:0048471)

Description
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. {Experimental EvidencePubMed:1824724}.
Assigned Ontology terms

Biological Process	In Utero Embryonic Development (GO:0001701) Mannose Metabolic Process (GO:0006013) Protein N-Linked Glycosylation (GO:0006487) Protein N-Linked Glycosylation Via Asparagine (GO:0018279) UDP-N-Acetylglucosamine Catabolic Process (GO:0006049)
Molecular Function	Alpha-1,3-Mannosylglycoprotein 2-Beta-N-Acetylglucosaminyltransferase Activity (GO:0003827) Manganese Ion Binding (GO:0030145) Protein N-Acetylglucosaminyltransferase Activity (GO:0016262)

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