NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Interferon-induced GTP-binding protein Mx1 - Sus scrofa - NucEnvDB

Interferon-induced GTP-binding protein Mx1 (Sus scrofa)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Interferon-induced GTP-binding protein Mx1
Accession Code	P27594
Gene	MX1
Organism	Sus scrofa \| Pig (Taxonomy: 9823)
Part of Reference Proteome?	Yes
Sequence (Length: 663)
MVYSSCESKEPDSVSASNHLLLNGNDELVEKSHKTGPENNLYSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEEDEWKGKVSYRDS EIELSDASQVEKEVSAAQIAIAGEGVGISHELISLEVSSPHVPDLTLIDLPGITRVAVGNQPYDIEYQIKSLIKKYICKQETINLVVVPCNVDIATTEALRMAQEVDPEGDRTIGILTKPDLVDKGTEDK IVDVARNLVFHLKKGYMIVKCRGQQDIQEQLSLAKALQKEQAFFENHAHFRDLLEEGRATIPCLAERLTSELIMHICKTLPLLENQIKESHQKITEELQKYGSDIPEDESGKMFFLIDKIDAFNSDITAL IQGEELVVEYECRLFTKMRNEFCRWSAVVEKNFKNGYDAICKQIQLFENQYRGRELPGFVNYKTFETIIKKQVSVLEEPAVDMLHTVTDLVRLAFTDVSETNFNEFFNLHRTAKSKIEDIKLEQEKEAET SIRLHFQMEQIVYCQDQVYRGALQKVREKEAEEEKNRKSNQYFLSSPAPSSDPSIAEIFQHLIAYHQEVGKRISSHIPLIIQFFILRTFGQQLQKSMLQLLQNKDQYDWLLRERSDTSDKRKFLKERLMR LTQARRRLAKFPG

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:17203407, Experimental EvidencePubMed:19109387}. Endoplasmic reticulum membrane {By SimilarityUniProtKB:P20591}; Peripheral membrane protein {By SimilarityUniProtKB:P20591}; Cytoplasmic side {ECO:0000250}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P20591}. Note=Binds preferentially to negatively charged phospholipids. {By SimilarityUniProtKB:P20591}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:P20591}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Endoplasmic Reticulum Membrane (GO:0005789) Membrane (GO:0016020) Microtubule (GO:0005874) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. {Experimental EvidencePubMed:20167191}.
Assigned Ontology terms

Biological Process	Cellular Response To Type I Interferon (GO:0071357) Defense Response To Virus (GO:0051607) Endosomal Transport (GO:0016197) Negative Regulation Of Intracellular Transport Of Viral Material (GO:1901253) Negative Regulation Of Viral Genome Replication (GO:0045071)
Molecular Function	GTP Binding (GO:0005525) GTPase Activity (GO:0003924) Microtubule Binding (GO:0008017)

Cross-References

Database	Links
UNIPROT	P27594 Q1AHC4 Q75PY7
Pfam	PF01031 PF00350 PF02212
PROSITE	PS00410 PS51718 PS51388

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