Virion {By
Similarity}. Host cell membrane {By
Similarity}; Multi-pass membrane protein {By
Similarity}. Host endosome membrane {By
Similarity}; Multi-pass membrane protein {By
Similarity}. Host Golgi apparatus membrane {By
Similarity}; Multi-pass membrane protein {By
Similarity}. Host nucleus membrane {By
Similarity}; Multi-pass membrane protein {By
Similarity}. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with gK to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN) (By similarity). {By
Similarity}.
The host nuclear envelope is a membrane system which surrounds the host nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the host nuclear intermembrane space. Note: This location is defined for viral proteins that appear in the Nuclear Envelope of infected host cells
The membrane surrounding the host nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer host nuclear membrane. Note: This location is defined for viral proteins that appear in the Nuclear Membrane of infected host cells
Plays an essential role in egress of virus particles from the nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a functional protein complex with gK and this interaction is absolutely essential for their coordinate intracellular transport, gK glycosylation, expression on host cell surface, and function. Together, they modulate gB-mediated virus-induced cell fusion and virion egress and therefore actively participate in these processes (By similarity). {By
Similarity, Experimental EvidencePubMed:16352534}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory