National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | 2'-5'-oligoadenylate synthase 2 |
| Accession Code | P29728 |
| Gene | OAS2 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 719) |
Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Lipid-Anchored | UniProt | Experimental Evidence {ECO:0000269|PubMed:2211721} | Assigned Ontology terms |
Description |
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|---|---|
| Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:9880569, PubMed:11682059). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity). {By SimilarityUniProtKB:E9Q9A9, Experimental EvidencePubMed:10464285, Experimental EvidencePubMed:11682059, Experimental EvidencePubMed:19923450, Experimental EvidencePubMed:9880569, Curator InferencePubMed:21142819}. | Assigned Ontology terms |
Interactions with other proteins (5 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | P29728 A8K9T1 Q6PJ33 Q86XX8 |
| Pfam | PF01909 PF10421 |
| PROSITE | PS00832 PS00833 PS50152 |
| OMIM | 603350 |
| DisGeNET | 4939 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory