NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Inositol 1,4,5-trisphosphate receptor type 1 - Rattus norvegicus - NucEnvDB

Inositol 1,4,5-trisphosphate receptor type 1 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Inositol 1,4,5-trisphosphate receptor type 1
Accession Code	P29994
Gene	Itpr1
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 2750)
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGA NSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSW FYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDP DFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVH STNIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVL RHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVS MNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAK EGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQVTP VKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYN FSDLLRLTKILLAILDCVHVTTIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEP EKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETSSGNSSQEGPSNVPGALDFEHIEEQAEGI FGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLD QLRSIVEKSELWVYKGQGPDEPMDGASGENEHKKTEEGTSKPLKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQ QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNN FQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRS ERDRMDENSPLFMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE IYTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVY HCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHNIVQKTAMNWRLSARNAARRDSVLAASRDYRNI IERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR EMMTKDRGYGEKQISIDELENAELPQPPEAENSTEQELEPSPPLRQLEDHKRGEALRQILVNRYYGNIRPSGRRESLTSF GNGPLSPGGPSKPGGGGGGPGSGSTSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVRDQLLEAS AATRKAFTTFRREADPDDHYQSGEGTQATTDKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLV CETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGENGEDGAASPRNVGHNIYILA HQLARHNKELQTMLKPGGQVDGDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKI NDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLL ICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRPIILTAALALILVYLFSIVGYLFFKDDFILEVDRLPNETAG PETGESLANDFLYSDVCRVETGENCTSPAPKEELLPVEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWH YLCFIVLVKVKDSTEYTGPESYVAEMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELK DQMTEQRKQKQRIGLLGHPPHMNVNPQQPA

Structure Viewer (PDB: 6MU1)

Subcellular Location

Description
Endoplasmic reticulum membrane {By SimilarityUniProtKB:Q9TU34}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasmic vesicle, secretory vesicle membrane {By SimilarityUniProtKB:Q9TU34}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasm, perinuclear region {ECO:0000250\|UniProtKB:Q14643}. Note=Endoplasmic reticulum and secretory granules (By similarity). {By SimilarityUniProtKB:Q9TU34}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Calcineurin Complex (GO:0005955) Cytoplasm (GO:0005737) Cytoplasmic Vesicle Membrane (GO:0030659) Dendrite (GO:0030425) Endoplasmic Reticulum (GO:0005783) Endoplasmic Reticulum Membrane (GO:0005789) GABA-Ergic Synapse (GO:0098982) Obsolete Integral Component Of Endoplasmic Reticulum Membrane (GO:0030176) Intracellular Membrane-Bounded Organelle (GO:0043231) Membrane Raft (GO:0045121) Neuronal Cell Body (GO:0043025) Nuclear Envelope (GO:0005635) Nuclear Inner Membrane (GO:0005637) Nucleolus (GO:0005730) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Platelet Dense Granule Membrane (GO:0031088) Platelet Dense Tubular Network (GO:0031094) Postsynapse (GO:0098794) Postsynaptic Density (GO:0014069) Presynapse (GO:0098793) Protein-Containing Complex (GO:0032991) Sarcoplasmic Reticulum (GO:0016529) Schaffer Collateral - CA1 Synapse (GO:0098685) Secretory Granule Membrane (GO:0030667) Smooth Endoplasmic Reticulum Membrane (GO:0030868) Synapse (GO:0045202) Synaptic Membrane (GO:0097060) Transport Vesicle Membrane (GO:0030658)

Biology & Function

Description
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. {By SimilarityUniProtKB:P11881}.
Assigned Ontology terms

Biological Process	Calcium Ion Transport (GO:0006816) Cell Morphogenesis (GO:0000902) Cellular Response To CAMP (GO:0071320) Cellular Response To Hypoxia (GO:0071456) Dendrite Development (GO:0016358) Endoplasmic Reticulum Calcium Ion Homeostasis (GO:0032469) Epithelial Fluid Transport (GO:0042045) Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress (GO:0070059) Liver Regeneration (GO:0097421) Negative Regulation Of Calcium-Mediated Signaling (GO:0050849) Negative Regulation Of Neuron Death (GO:1901215) Positive Regulation Of Apoptotic Process (GO:0043065) Positive Regulation Of Calcium Ion Transport (GO:0051928) Positive Regulation Of Cytosolic Calcium Ion Concentration (GO:0007204) Positive Regulation Of Hepatocyte Proliferation (GO:2000347) Positive Regulation Of Neuron Projection Development (GO:0010976) Post-Embryonic Development (GO:0009791) Release Of Sequestered Calcium Ion Into Cytosol (GO:0051209) Response To Hypoxia (GO:0001666) Voluntary Musculoskeletal Movement (GO:0050882)
Molecular Function	Calcium Channel Inhibitor Activity (GO:0019855) Calcium Ion Binding (GO:0005509) Calcium-Release Channel Activity (GO:0015278) Identical Protein Binding (GO:0042802) Inositol 1,4,5 Trisphosphate Binding (GO:0070679) Inositol 1,4,5-Trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels (GO:0098695) Inositol 1,4,5-Trisphosphate-Sensitive Calcium-Release Channel Activity (GO:0005220) Phosphatidylinositol Binding (GO:0035091) Protein C-Terminus Binding (GO:0008022) Protein Domain Specific Binding (GO:0019904) Protein Phosphatase Binding (GO:0019903) Protein-Containing Complex Binding (GO:0044877) Transmembrane Transporter Binding (GO:0044325)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P29994	Self	EBI-15939786	0.53
Interactions with other proteins (9 interactors)

Partner (UniProt)		IntAct	Confidence score
Q96RG2	PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)	EBI-8614700	0.44
P54256	Huntingtin-associated protein 1 (HAP-1)	EBI-9674257	0.58
P51111	Huntingtin (Huntington disease protein homolog) (HD protein homolog) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	EBI-9674682	0.52
P42858	Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	EBI-9674812	0.52
P31749	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)	EBI-15683723	0.40
Q3U182	CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)	EBI-15980711	0.40
P19332	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	EBI-26374040	0.35
Q5XIE8	Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]	EBI-26438079	0.35
F1M0Z1	Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)	EBI-26961439	0.35

Cross-References

Database	Links
UNIPROT	P29994 Q62869
PDB	3JAV 3T8S 3UJ0 3UJ4 6MU1 6MU2 7LHE 7LHF
Pfam	PF08709 PF00520 PF02815 PF08454 PF01365
PROSITE	PS50919

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