National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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| Protein Name | Cell death protein 4 |
| Accession Code | P30429 |
| Gene | ced |
| Organism | Caenorhabditis elegans (Taxonomy: 6239) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 571) |
Structure Viewer (PDB: 4M9Z) |
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Description |
Position in the Nuclear Envelope |
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| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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| Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development (PubMed:3955651). During oogenesis, required for germline apoptosis downstream of ced-9 and upstream of ced-3 but independently of egl-1 (PubMed:9927601). May regulate germline apoptosis in response to DNA damage, probably downstream of let-60/ras and mpk-1 pathway (PubMed:21901106). Regulates CEP neuron apoptosis in response to high Al(3+) levels (PubMed:23106139). During male tail morphogenesis, promotes apoptosis of the tail-spike cell upstream of ced-3 but independently of egl-1 and ced-9 (PubMed:17329362). May play a role in sex-specific cell apoptosis, probably by promoting ced-3-mediated cleavage of sex-determining protein fem-1 (PubMed:10764728). During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and ced-9 and upstream of ced-3 apoptotic pathway (PubMed:26074078). Downstream of calreticulin crt-1 and upstream of ced-3 and independently of egl-1 and ced-9, plays a role in the initial steps of axonal regrowth following axotomy (PubMed:22629231). Together with ain-1, a component of the miRNA- induced-silencing complex (miRISC), and probably upstream of ced-3, regulates temporal cell fate patterning during larval development (PubMed:25432023). May play a role in resistance to S.typhimurium- mediated infection (PubMed:11226309). {Experimental EvidencePubMed:10764728, Experimental EvidencePubMed:11226309, Experimental EvidencePubMed:17329362, Experimental EvidencePubMed:21901106, Experimental EvidencePubMed:22629231, Experimental EvidencePubMed:23106139, Experimental EvidencePubMed:25432023, Experimental EvidencePubMed:26074078, Experimental EvidencePubMed:3955651, Experimental EvidencePubMed:9927601}. [Isoform a]: Plays a major role in programmed cell death (PubMed:1286611, PubMed:8706125). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to induce caspase ced-3 autoproteolytic cleavage and activation (PubMed:15383288, PubMed:16208361, PubMed:20434985, PubMed:24065769). Also forms a holoenzyme with processed ced-3 enhancing ced-3 activity (PubMed:20434985). {Experimental EvidencePubMed:10688797, Experimental EvidencePubMed:1286611, Experimental EvidencePubMed:15383288, Experimental EvidencePubMed:16208361, Experimental EvidencePubMed:20434985, Experimental EvidencePubMed:24065769, Experimental EvidencePubMed:8706125}. [Isoform b]: Prevents programmed cell death. {Experimental EvidencePubMed:8706125}. | Assigned Ontology terms |
Interactions with Nuclear Envelope proteins (4 interactors) |
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Interactions with other proteins (4 interactors) |
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Database | Links |
| UNIPROT | P30429 Q5BHI5 |
| PDB | 2A5Y 3LQQ 3LQR 4M9S 4M9X 4M9Y 4M9Z |
| Pfam | PF00619 PF00931 |
| PROSITE | PS50209 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory