NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Interferon-induced GTP-binding protein Mx1 - Ovis aries - NucEnvDB

Interferon-induced GTP-binding protein Mx1 (Ovis aries)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Interferon-induced GTP-binding protein Mx1
Accession Code	P33237
Gene	MX1
Organism	Ovis aries \| Sheep (Taxonomy: 9940)
Part of Reference Proteome?	Yes
Sequence (Length: 654)
MVLSDLDIKEPDSPESGLNGSDDMVREHETESKGNLYSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLRLKKLEKEGEWKGKVSFLDREIEISD ASQVEKEISEAQIAIAGEGMGISHELISLEVSSPHVPDLTLIDLPGITRVAVGNQPHDIEYQIKSLIRKYILRQETINLVVVPANVDIATTEALRMAQDVDPQGDRTIGILTKPDLVDKGTEDKVVDVVR NLVFHLKKGYMIVKCRGQQEIQHRLSLDKALQRERIFFEDHTHFRDLLEEGRATIPCLAERLTNELIMHICKTLPLLENQIKETHQRITEELQKYGKDIPEEESEKMFSLIEKIDTFNKEIISTIEGEEH VGQYDSRLFTKVRAEFCKWSAVVEKNFEKGHEAIRKEIKQFENRYRGRELPGFVNYKTFEIIIKKQVIVLEEPAVDMLHTVTDIIRNTFTEVSGKHFSEFFNLHRTAKSKIEDIRLEQENEAEKSIRLHF QMEQLVYCQDQVYRRALQQVREKEAEEEKKKKSNHYYQSEDSEPSTAEIFQHLMAYHQEVSTRISSHIPLIIQFFVLRTYGEQLKKSMLQLLQDKDQYDWLLKERTDTRDKRKFLKERLERLSRARQRLA KFPG

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:P20591}. Endoplasmic reticulum membrane {By SimilarityUniProtKB:P20591}; Peripheral membrane protein {By SimilarityUniProtKB:P20591}; Cytoplasmic side {By SimilarityUniProtKB:P20591}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P20591}. Note=Binds preferentially to negatively charged phospholipids. {By SimilarityUniProtKB:P20591}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:P20591}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Endoplasmic Reticulum Membrane (GO:0005789) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Interferon-induced dynamin-like GTPase with antiviral activity. {By Similarity}.
Assigned Ontology terms

Biological Process	Innate Immune Response (GO:0045087)
Molecular Function	GTP Binding (GO:0005525) GTPase Activity (GO:0003924)

Cross-References

Database	Links
UNIPROT	P33237 Q95MD4
Pfam	PF01031 PF00350 PF02212
PROSITE	PS00410 PS51718 PS51388

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