National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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| Protein Name | Chitinase-3-like protein 1 |
| Accession Code | P36222 |
| Gene | CHI3L1 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 383) |
Structure Viewer (PDB: 1HJX) |
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Description |
Position in the Nuclear Envelope |
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| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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| Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia- induced injury, inflammation and epithelial apoptosis in lung. {Experimental EvidencePubMed:16472595, Experimental EvidencePubMed:19414556, Experimental EvidencePubMed:20558631, Experimental EvidencePubMed:9492324}. | Assigned Ontology terms |
Description |
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| Asthma-related traits 7 (ASRT7) [MIM:611960]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {Experimental EvidencePubMed:18403759}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Schizophrenia (SCZD) [MIM:181500]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {Experimental EvidencePubMed:17160890, Experimental EvidencePubMed:20051317}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. | Database Associations |
| OMIM | 181500 601525 611960 |
| DisGeNET | 1116 |
Interactions with other proteins (10 interactors) |
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Database | Links |
| UNIPROT | P36222 B2R7B0 P30923 Q8IVA4 Q96HI7 |
| PDB | 1HJV 1HJW 1HJX 1NWR 1NWS 1NWT 1NWU 7CJ2 |
| Pfam | PF00704 |
| PROSITE | PS51910 |
| OMIM | 181500 601525 611960 |
| DisGeNET | 1116 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory