NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Inactive glutathione hydrolase 2 - Homo sapiens - NucEnvDB

Inactive glutathione hydrolase 2 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Inactive glutathione hydrolase 2
Accession Code	P36268
Gene	GGT2P
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 569)
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAMAADAKQCLEIGRDTLRDGGSAVDAAIAALLCVGLMNAHSMGIGVGLFLTIYNSTTGKAEVINAREVAPRLAFASMFNSSEQSQKGGL SVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAVLENKRTVIEQQPVLWYVFCRDRKVLREGERLTLPRLADTYEMLAIEGAQAFYNGSLMAQIVKDIQAAGGIVTAEDLNNYRAEL IEHPLNISLGDAVLYMPSARLSGPVLALILNILKGYNFSRESVETPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRSQISDHTTHPISYYKPEFYTPDDGGTAHLSVVAED GSAVSATSTINLYFGSKVCSPVSGILFNNEWTTSALPAFTNEFGAPPSPANFIQPGKQPLLSMCLTIMVGQDGQVRMVVGAAGGTQITTDTALAIIYNLWFGYDVKRAVEEPRLHNKLLPNVTTVERNID QAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAALDSRKGGEPAGY

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:23682772}. Endoplasmic reticulum {Experimental EvidencePubMed:23682772}. Note=Co-localizes with calnexin in the endoplasmic reticulum.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Endoplasmic Reticulum (GO:0005783) Extracellular Exosome (GO:0070062) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
[Isoform 1]: Lacks catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {Experimental EvidencePubMed:23682772}. [Isoform 2]: Lacks catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {Experimental EvidencePubMed:23682772}. [Isoform 3]: Lacks catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {Experimental EvidencePubMed:23682772}.
Assigned Ontology terms

Biological Process	Glutathione Catabolic Process (GO:0006751) Leukotriene D4 Biosynthetic Process (GO:1901750) Peptide Modification (GO:0031179) Regulation Of Immune System Process (GO:0002682) Regulation Of Inflammatory Response (GO:0050727)
Molecular Function

Cross-References

Database	Links
UNIPROT	P36268
PROSITE	PS00462
OMIM	137181

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