NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Uncharacterized transcriptional regulatory protein TBS1 - Saccharomyces cerevisiae S288C - NucEnvDB

Uncharacterized transcriptional regulatory protein TBS1 (Saccharomyces cerevisiae S288C)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Uncharacterized transcriptional regulatory protein TBS1
Accession Code	P38114
Gene	TBS1
Organism	Saccharomyces cerevisiae S288C (Taxonomy: 559292)
Part of Reference Proteome?	Yes
Sequence (Length: 1094)
MNMDSGITSSHGSMDKTQKQSSEWAANQKHNQRVENTRVLMGPAVPAMPPVPSNFPPVPTGTIMSPQLSPFPDHRLRHHPLAHMMPADKNFLAYNMESFKSRVTKACDYCRKRKIRCTEIEPISGKCRNC IKYNKDCTFHFHEELKRRREEALNNKGNGKSVKKPRLDKENKFKDENFDIAVRSRNTSSTDSSPKLHTNLSQEYIGVSAGKSASDKEDTWPDFVPIDRTVLEKIELNHTKVAGKVFVLEEICKNMKGTIE KLAEKSKIDVIDKEYMKRPKRKQYSKALLTKQKMFHFRQNVLSHLTDEEFLSPINEMFTTTFKYSILQTKLVLDFSFRSASSPSSDNILYPLPRLAIAKRLLKNIKCPSLASLLHIVDVDQCLQFADVHF DPAKGRLTSSQAFLLNICLCLGATVTNFEEKQELVDEDNHETYYFEKFELWRLRSFTFLNSVYYYHKLSVARADMTALKALLLLAKFAQQKISASSAVKVLSVAIKVALDLRLNLHSTYEDLELDEIIKR RRLWCYCFSTDKFFSVVLSRPPFLKEENTDVLTDESYVELFRDKILPNLSIKYDDSKLEGVKDIVSVVNLLANHLEYVPYIQSYFLSRLSLIESQIYYSCFSIRTTLDDTLDEIIENVLENQKALDRMRD DLPTILSLENYKENMRILSLDSSKLDFEVSCCTTILLHLRWYHQKITLSLFVISIIGDNLDQRESSRHDIAEIIRRSRLDFKRNCIEVLNILKDFEYYPTVQNEFLYFSLTTVFSMFLYLSEIMVNDEHA METGYIIGLLRDTHTRMLGSEERCLSVHNLKWQTSLFFYTFFLRSTMEKFNLTSKYAKFYAFDSNYYEGVLNRLVKHTRESKDDMVELLKTSFINKEKMAAFGSFVTEDQEKMEVSFNIFNEITIQDLNF LQFSSIPKLWENKTLEPGEEYHHSNGTNTDNNETTGADDTDDNNNNNNNNNKNGNNSSSTINNNNNNYSNSNNNDNDNNINDDDDDDDDDDDDDDDDDDDDDNDDDYSNNGADDDEEDDDYDRSLFPTGL ASLLDASYPERTANDYRDENEQSNKLFEKIEGHLEHGVFFYDRDFFFKNVCVKM

Subcellular Location

Description
Nucleus membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Nuclear Membrane	SL-0182	The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Mitochondrial Membrane (GO:0031966) Mitochondrion (GO:0005739) Nuclear Membrane (GO:0031965) Nucleus (GO:0005634)

Biology & Function

Description
Involved in tolerance to thiabendazole. {Experimental EvidencePubMed:10628851}.
Assigned Ontology terms

Biological Process
Molecular Function	DNA-Binding Transcription Factor Activity, RNA Polymerase II-Specific (GO:0000981) Sequence-Specific DNA Binding (GO:0043565) Zinc Ion Binding (GO:0008270)

Protein-Protein Interactions

Interactions with other proteins (15 interactors)

Partner (UniProt)		IntAct	Confidence score
Q12019	Midasin (Dynein-related AAA-ATPase REA1) (MIDAS-containing protein) (Ribosome export/assembly protein 1)	EBI-7777540	0.44
Q12343	Mediator of RNA polymerase II transcription subunit 4 (Mediator complex subunit 4)	EBI-2344772	0.37
Q12180	Halotolerance protein 9	EBI-2346028	0.37
P39743	Reduced viability upon starvation protein 167	EBI-7481040	0.37
P32790	Actin cytoskeleton-regulatory complex protein SLA1	EBI-7491226	0.37
P10591	Heat shock protein SSA1 (Heat shock protein YG100)	EBI-3773814	0.35
P11484	Ribosome-associated molecular chaperone SSB1 (EC 3.6.4.10) (Cold-inducible protein YG101) (Heat shock protein SSB1) (Hsp70 chaperone Ssb)	EBI-3784377	0.35
P38788	Ribosome-associated complex subunit SSZ1 (DnaK-related protein SSZ1) (Heat shock protein 70 homolog SSZ1) (Pleiotropic drug resistance protein 13)	EBI-3791956	0.35
P10592	Heat shock protein SSA2	EBI-3795924	0.35
P32589	Heat shock protein homolog SSE1 (Chaperone protein MSI3)	EBI-3807996	0.35
P02829	ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)	EBI-3814684	0.35
P53900	Prefoldin subunit 4 (Genes involved in microtubule biogenesis protein 3) (Gim complex subunit 3) (GimC subunit 3)	EBI-3821621	0.35
P39078	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta)	EBI-3822865	0.35
Q12329	Heat shock protein 42 (42 kDa heat shock protein)	EBI-3829736	0.35
P07703	DNA-directed RNA polymerases I and III subunit RPAC1 (RNA polymerases I and III subunit AC1) (C37) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (AC40) (C40)	EBI-16280355	0.35

Cross-References

Database	Links
UNIPROT	P38114 D6VQE5 E9PAD3
Pfam	PF04082 PF00172
PROSITE	PS00463 PS50048

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