NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

5'-3' exoribonuclease 1 - Schizosaccharomyces pombe 972h- - NucEnvDB

5'-3' exoribonuclease 1 (Schizosaccharomyces pombe 972h-)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	5'-3' exoribonuclease 1
Accession Code	P40383
Gene	exo2
Organism	Schizosaccharomyces pombe 972h- (Taxonomy: 284812)
Part of Reference Proteome?	Yes
Sequence (Length: 1328)
MGIPKFFRWMSERYPLCSQLIENDRIPEFDNLYLDMNGILHNCTHKNDDHSSPPLPEEEMYIAIFNYIEHLFEKIKPKKLLYMAVDGCAPRAKMNQQRSRRFRTAKDAHDARLKAERNGEDFPEEQFDSN CITPGTTFMERVSRQLYYFIHKKVTNDSQWQNIEVIFSGHDCPGEGEHKIMEYIRTQKAQPSYNPNTRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGPASRNRSKELAHQKFYLLHLSLLREYLEFE FQECRSTFTFKYDLEKILDDFILLAFFVGNDFLPHLPGLHINEGALALMFSIYKKVMPSAGGYINEKGVINMARLELILLELENFEKEIFKAEVSETKNNGNSDKPSFDFLKYITESTNDIKAMTGEQKN YFLQIKKFLSSREPFIDFSANISSVDQRFLRRLCNDLHLSFSKIIKVDGTHLLRITFRDLEFNDEDEDEIEQDEIERVLQKYDNIPLLNEEQALKEKNVEKDFIQWKDDYYRSKVGFSYYDEEALKAMAE RYVEGLQWVLFYYYRGCQSWGWYYNYHFAPKISDVLKGLDVKIDFKMGTPFRPFEQLMAVLPARSQALVPPCFRDLMVNSESPIIDFYPENFALDQNGKTASWEAVVIIPFIDETRLIDALASKDKFLTE EERKRNSFNAPTVFSLAEDYTSFYPSSLPSLFPDLVTRCIQKPYSLPSMEGKEYLVGLCPGVFLGAFGMVGFPSFHTLKHKAELVYHGINVFGNESRNPSVIVNVEDVKSALTSEQIAMQYVGKRIFVDW PYLREAYVESAMDESYMYLASNSTIEKRDLAEIEKSQWGRKCSHKIREYSKRFGVLFGDISLLLQVRPIKGLEYTREGALVKIFNESVLEDYPAQLVVEKIAIDDPRFTEREAPPVEVEYPPGTKAFHLG EYNYGRPAQITGCKDNKLIIWLSTAPGLDAQWGRVLVNDSKSKEKYYPSYIVAKLLNIHPLLLSKITSSFLISNGTKRENIGLNLKFDARNQKVLGFSRKSTKGWEFSNKTVALVKEYINTFPQLFNILT THATKDNLTVKDCFPKDDTQQLAAVKHWIKEKGINSLTRVSLDEDALDSDIIKLIEEKASTIDSTYQVPKKVFGVPRYALLKPSQTRGILHSQEFALGDRVVYVQDSGKVPIAAYGTVVGIMLHHLDVVF DLPFMSGTTLDGRCSPYHGMQVEVSMVLNVTNPQFVVNTRAGKNRKTNVSANNVSQGTDSRLVTKPTSTFPSPPSPPSSSVWNKREHHPKPFSLHQVPPPESLIHKSKSKFSKGNHHSTNGTQSIRGRGG KRGKPLRSKELNRKHDHIVQPMGKLQIN

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:16823372}. Cytoplasm, perinuclear region {By Similarity}. Cytoplasm, P-body {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytoplasmic Stress Granule (GO:0010494) Cytosol (GO:0005829) Nucleus (GO:0005634) P-Body (GO:0000932) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Multifunctional protein that exhibits several independent functions at different levels of the cellular processes (PubMed:8188690, PubMed:1637812). 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins (By similarity). Involved in the degradation of several hypomodified mature tRNA species and participates in the 5'-processing or the degradation of the snoRNA precursors and rRNA processing (By similarity). {By SimilarityUniProtKB:P22147, Experimental EvidencePubMed:1637812, Experimental EvidencePubMed:8188690}.
Assigned Ontology terms

Biological Process	Nuclear-Transcribed MRNA Catabolic Process (GO:0000956) Nuclear-Transcribed MRNA Catabolic Process, Nonsense-Mediated Decay (GO:0000184) RRNA Catabolic Process (GO:0016075) RRNA Processing (GO:0006364)
Molecular Function	5'-3' Exoribonuclease Activity (GO:0004534) Magnesium Ion Binding (GO:0000287) Ribonuclease Activity (GO:0004540) RNA Binding (GO:0003723)

Cross-References

Database	Links
UNIPROT	P40383
Pfam	PF18129 PF18332 PF18334 PF18194 PF17846 PF03159

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK