NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Atrophin-1 - Rattus norvegicus - NucEnvDB

Atrophin-1 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Atrophin-1
Accession Code	P54258
Gene	Atn1
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 1183)
MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEETSTPKANKQGRSEEISESESEETSAPKKTKTEELPRPQSPSDLDSLDGRSINDDGSSDPRDIDQDNRST SPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPPPPDSIPRQPESGFEPHPSVPPTGYHAPMEPPTSRLFQGPPPGAPPPHPQLYPGSAGGGVLSGPPMGPKGGAAASSVGPPSGGKQHPPPTTP IPISSSGASGAPPAKPPNTPVGAGNLPSAPPPATFPHVTPNLPPPPALRPLNNASASPPGMGAQPIPGHLPSPHAMGQGMSGLPPGPEKGPTLAPSPHPLPPASSSAPGPPMRYPYSSCSSSSVAASSSS SAATSQYPASQTLPSYPHSFPPPTSMSVSNQPPKYTQPSLPSQAVWSQGPPPPPPPYGRLLPNNNTHPGPFPPTGGQSTAHPPAPAHHHHQQQQQPQPQPQPQQHHHGNSGPPPPGAYPHPLESSNSHHA HPYNMSPSLGSLRPYPPGPAHLPPSHGQVSYSQAGPNGPPVSSSSNSSGSSSQAAYSCSHPSSSQGPQGASYPFPPVPPITTSSATLSTVIATVASSPAGYKTASPPGPPQYSKRAPSPGSYKTATPPGY KPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSSLSSLPPPPAAPTTGPPLTATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPL EGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLG YNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQMLNV TPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQED YYSHLKKESDKPL

Subcellular Location

Description
Nucleus {Experimental EvidencePubMed:19131340}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:19131340}. Cell junction {Experimental EvidencePubMed:19131340}. Note=Shuttles between nucleus and cytoplasm. Colocalizes with MTG8 in discrete nuclear dots (By similarity). Colocalizes with FAT1 in the perinuclear area, at cell- cell junctions and leading edges of cells. {ECO:0000250\|UniProtKB:O35126}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Cell Leading Edge (GO:0031252) Cytoplasm (GO:0005737) Nuclear Matrix (GO:0016363) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity (By similarity). {By SimilarityUniProtKB:O35126}.
Assigned Ontology terms

Biological Process	Cell Killing (GO:0001906) Cell Migration (GO:0016477) Determination Of Adult Lifespan (GO:0008340) Maintenance Of Cell Polarity (GO:0030011) Male Gonad Development (GO:0008584) Multicellular Organism Growth (GO:0035264) Negative Regulation Of DNA-Templated Transcription (GO:0045892) Negative Regulation Of Transcription By RNA Polymerase II (GO:0000122) Neuron Apoptotic Process (GO:0051402) Positive Regulation Of DNA-Templated Transcription (GO:0045893) Post-Embryonic Development (GO:0009791) Regulation Of Neuron Differentiation (GO:0045664) Response To Food (GO:0032094) Spermatogenesis (GO:0007283) Toxin Metabolic Process (GO:0009404)
Molecular Function	JUN Kinase Binding (GO:0008432) Protein Domain Specific Binding (GO:0019904) Toxin Activity (GO:0090729) Transcription Coactivator Activity (GO:0003713) Transcription Corepressor Activity (GO:0003714)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
Q6GMN2	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)	EBI-6997460	0.40
Q9BYV2	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30)	EBI-21999534	0.35

Cross-References

Database	Links
UNIPROT	P54258
Pfam	PF03154

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