NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Hypoxia-inducible factor 1-alpha inhibitor - Danio rerio - NucEnvDB

Hypoxia-inducible factor 1-alpha inhibitor (Danio rerio)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Hypoxia-inducible factor 1-alpha inhibitor
Accession Code	P59723
Gene	hif1an
Organism	Danio rerio \| Zebrafish (Taxonomy: 7955)
Part of Reference Proteome?	Yes
Sequence (Length: 344)
MAETDGAAAFTELRDPDWDESQLRQYTFPTRQIPRLSHTDPRAEVLINNEEPVVLTDTSLVYPALKWDIPYLQENIGNGDFSVYIAENHKFLYYDEKKMVNFQDFVPKSRRIEMKFSEFVDKMHQTEEQG GKGRVYLQQTLNDTVGRKIVVDFLGFNWNWINKQQAKRNWGPLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGHKRCILFPPDQFDCLYPYPVHHPCDRQSQVDFENPDYDKFPNFKNAVGYEAVVGPGD VLYIPMYWWHHIESLLNGGETITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGDPHEVGPLLNMMIKGRYDHGLS

Subcellular Location

Description
Nucleus {By SimilarityUniProtKB:Q9NWT6}. Cytoplasm {By SimilarityUniProtKB:Q9NWT6}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q9NWT6}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Hydroxylates a specific Asn residue in the C-terminal transactivation domain (CAD) of HIF-1 alpha. The hydroxylation prevents interaction of HIF-1 with transcriptional coactivators. Also hydroxylates specific Asn, Asp and His residues within ankyrin repeat domain-containing proteins. {By SimilarityUniProtKB:Q9NWT6}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Notch Signaling Pathway (GO:0045746) Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia (GO:0061428) Negative Regulation Of Vasculature Development (GO:1901343) Obsolete Peptidyl-Asparagine Hydroxylation (GO:0042265) Peptidyl-Aspartic Acid Hydroxylation (GO:0042264) Peptidyl-Histidine Hydroxylation (GO:0036138) Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway (GO:0030947)
Molecular Function	2-Oxoglutarate-Dependent Dioxygenase Activity (GO:0016706) Ankyrin Repeat Binding (GO:0071532) Carboxylic Acid Binding (GO:0031406) Ferrous Iron Binding (GO:0008198) [Protein]-Asparagine 3-Dioxygenase Activity (GO:0036140) Peptidyl-Histidine Dioxygenase Activity (GO:0036139) Protein Homodimerization Activity (GO:0042803) Zinc Ion Binding (GO:0008270)

Cross-References

Database	Links
UNIPROT	P59723 B8A5K4
Pfam	PF13621
PROSITE	PS51184

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