NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Neuronal calcium sensor 1 - Gallus gallus - NucEnvDB

Neuronal calcium sensor 1 (Gallus gallus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Neuronal calcium sensor 1
Accession Code	P62167
Gene	NCS1
Organism	Gallus gallus \| Chicken (Taxonomy: 9031)
Part of Reference Proteome?	Yes
Sequence (Length: 190)
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQ MVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV

Subcellular Location

Description
Golgi apparatus {By SimilarityUniProtKB:P62166}. Postsynaptic density {By SimilarityUniProtKB:P62166}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P62166}. Cytoplasm {ECO:0000250\|UniProtKB:P62168}. Cell membrane {By SimilarityUniProtKB:P62166}; Peripheral membrane protein {By SimilarityUniProtKB:P62166}. Membrane {ECO:0000250\|UniProtKB:P62168}; Lipid-anchor {By SimilarityUniProtKB:P62166}. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {By SimilarityUniProtKB:P62166}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250}
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Golgi Apparatus (GO:0005794) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Postsynaptic Density (GO:0014069)

Biology & Function

Description
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin.
Assigned Ontology terms

Biological Process	Regulation Of Neuron Projection Development (GO:0010975)
Molecular Function	Calcium Ion Binding (GO:0005509) Calcium Sensitive Guanylate Cyclase Activator Activity (GO:0008048) Voltage-Gated Calcium Channel Activity (GO:0005245)

Cross-References

Database	Links
UNIPROT	P62167 P36610 Q9UK26
Pfam	PF00036 PF13499
PROSITE	PS00018 PS50222

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