National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Myotrophin |
| Accession Code | P62775 |
| Gene | Mtpn |
| Organism | Rattus norvegicus | Norway rat (Taxonomy: 10116) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 118) |
Structure Viewer (PDB: 2MYO) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. {By Similarity, Experimental EvidencePubMed:17041682, Experimental EvidencePubMed:18693253}. | Assigned Ontology terms |
Interactions with other proteins (1 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | P62775 P80144 Q58HB3 Q9DCN8 |
| PDB | 1MYO 2MYO |
| Pfam | PF12796 |
| PROSITE | PS50297 PS50088 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory