National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | GTP-binding nuclear protein Ran |
| Accession Code | P62825 |
| Gene | RAN |
| Organism | Canis lupus familiaris | Dog (Taxonomy: 9615) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 216) |
Structure Viewer (PDB: 1WA5) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. {By SimilarityUniProtKB:P62826}. | Assigned Ontology terms |
Interactions with Nuclear Envelope proteins (1 interactors) |
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Interactions with other proteins (1 interactors) |
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Database | Links |
| UNIPROT | P62825 P17080 P28746 P28747 Q9CSP3 Q9CWI7 Q9CZA2 Q9UDJ5 Q9UEU9 |
| PDB | 1A2K 1BYU 1QG2 1QG4 1WA5 2BKU 3A6P 3RAN 3W3Z 5BXQ 5YU6 |
| Pfam | PF00071 |
| PROSITE | PS51418 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory