NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Ras-related protein Rap-1A - Rattus norvegicus - NucEnvDB

Ras-related protein Rap-1A (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Ras-related protein Rap-1A
Accession Code	P62836
Gene	Rap1a
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 184)
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQ GQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL

Subcellular Location

Description
Cell membrane {By Similarity}; Lipid-anchor {By Similarity}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:17724123}. Early endosome {ECO:0000269\|PubMed:17724123}. Late endosome {ECO:0000269\|PubMed:17724123}. Cytoplasm {By Similarity}. Cell junction {By Similarity}. Note=Localized with RAPGEF2 at cell-cell junctions. Colocalized with RAPGEF2 in the perinuclear region (By similarity). Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250\|UniProtKB:P62834}
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Cell Junction (GO:0030054) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Early Endosome (GO:0005769) Glutamatergic Synapse (GO:0098978) Guanyl-Nucleotide Exchange Factor Complex (GO:0032045) Late Endosome (GO:0005770) Neuron Projection (GO:0043005) Perinuclear Region Of Cytoplasm (GO:0048471) Phagocytic Vesicle (GO:0045335) Plasma Membrane (GO:0005886) Presynapse (GO:0098793) Sperm Midpiece (GO:0097225)

Biology & Function

Description
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {By Similarity, Experimental EvidencePubMed:17724123}.
Assigned Ontology terms

Biological Process	Cellular Response To CAMP (GO:0071320) Cellular Response To Nerve Growth Factor Stimulus (GO:1990090) Cellular Response To Organic Cyclic Compound (GO:0071407) Cellular Response To Xenobiotic Stimulus (GO:0071466) Establishment Of Endothelial Barrier (GO:0061028) Liver Regeneration (GO:0097421) Negative Regulation Of Collagen Biosynthetic Process (GO:0032966) Negative Regulation Of Synaptic Vesicle Exocytosis (GO:2000301) Nerve Growth Factor Signaling Pathway (GO:0038180) Nervous System Development (GO:0007399) Positive Regulation Of ERK1 And ERK2 Cascade (GO:0070374) Positive Regulation Of Fc-Gamma Receptor Signaling Pathway Involved In Phagocytosis (GO:1905451) Positive Regulation Of Glucose Import (GO:0046326) Positive Regulation Of GTPase Activity (GO:0043547) Positive Regulation Of Neuron Projection Development (GO:0010976) Positive Regulation Of Protein Kinase Activity (GO:0045860) Positive Regulation Of Vasculogenesis (GO:2001214) Protein Localization To Plasma Membrane (GO:0072659) Rap Protein Signal Transduction (GO:0032486) Regulation Of Cell Junction Assembly (GO:1901888) Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane (GO:0098696) Response To Antineoplastic Agent (GO:0097327) Response To Carbohydrate (GO:0009743) Small GTPase Mediated Signal Transduction (GO:0007264) Synaptic Vesicle Exocytosis (GO:0016079)
Molecular Function	G Protein Activity (GO:0003925) GDP Binding (GO:0019003) GTP Binding (GO:0005525) GTPase Activity (GO:0003924) Guanyl-Nucleotide Exchange Factor Activity (GO:0005085) Protein-Containing Complex Binding (GO:0044877) Small GTPase Binding (GO:0031267)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
P80386	5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) (5'-AMP-activated protein kinase 40 kDa subunit)	EBI-16400563	0.35

Cross-References

Database	Links
UNIPROT	P62836 P10113
Pfam	PF00071
PROSITE	PS51421

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