NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Receptor of activated protein C kinase 1 - Gallus gallus - NucEnvDB

Receptor of activated protein C kinase 1 (Gallus gallus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Receptor of activated protein C kinase 1
Accession Code	P63247
Gene	RACK1
Organism	Gallus gallus \| Chicken (Taxonomy: 9031)
Part of Reference Proteome?	Yes
Sequence (Length: 317)
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK LWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWD LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR

Subcellular Location

Description
Cell membrane {By SimilarityUniProtKB:P63244}; Peripheral membrane protein {By SimilarityUniProtKB:P63244}. Cytoplasm {By SimilarityUniProtKB:P63244}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P63244}. Nucleus {By SimilarityUniProtKB:P63244}. Perikaryon {ECO:0000250\|UniProtKB:P68040}. Cell projection, dendrite {ECO:0000250\|UniProtKB:P68040}. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery (By similarity). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). {By SimilarityUniProtKB:P63244, ECO:0000250\|UniProtKB:P68040}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:P63244}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Dendrite (GO:0030425) Neuronal Cell Body (GO:0043025) Nucleus (GO:0005634) Perikaryon (GO:0043204) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Small Ribosomal Subunit (GO:0015935)

Biology & Function

Description
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Wnt Signaling Pathway (GO:0030178) Positive Regulation Of Gastrulation (GO:2000543) Positive Regulation Of Protein Phosphorylation (GO:0001934) Protein Ubiquitination (GO:0016567) Regulation Of Cell Division (GO:0051302) Regulation Of Establishment Of Cell Polarity (GO:2000114) Regulation Of Protein Localization (GO:0032880) Rescue Of Stalled Ribosome (GO:0072344) Signal Transduction (GO:0007165)
Molecular Function	Protein Kinase C Binding (GO:0005080) Ribosome Binding (GO:0043022)

Cross-References

Database	Links
UNIPROT	P63247 A5HUK6 P25388 P99049 Q5EVY1
Pfam	PF00400
PROSITE	PS00678 PS50082 PS50294

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