NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Phospholipase D1 - Rattus norvegicus - NucEnvDB

Phospholipase D1 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Phospholipase D1
Accession Code	P70496
Gene	Pld1
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 1074)
MSLRSEARVNTSTLQKIAADMSNLIENLDTRELHFEGEEVEYDASPGDPTAQEACIPFSSIYNTQGFKEPNIQIYLSGCPVKAQVLEVERFTSTSRMPSVNLYTIELTHGEFTWQVKRKFKHFQEFHREL LKYKAFIRIPIPTKRHTFRRQNVKEEPREMPSLPRSSENAIQEEQFFGRRKQLEDYLTKILKMPMYRNYHATTEFLDVSQLSFIHDLGPKGLEGMIMKRSGGHRIPGVNCCGHGRACYRWSKRWLIVKDS FLLYMKPDSGAIAFVLLVDKEFRIKVGKKETETKYGLRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTDFLKDHRFGSYAAVHENILAKWYVNAKGYFEDIANAMEGATEEIFITDWWLSPEIFLK RPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSSVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGQSLGSLTAASVESM ESLSLKDKHQSHKNEPVLKSVNDTDMKLKGIGKSRKFSKFSLYRQLHRRNLHNSDSISSVDSASSYFNHYRSHQNLIHGIKPHLKLFRPSSESEQGLTRHSADTGSIRSVQTGVGELHGETRFWHGKDYC NFVFKDWVQLDKPFADFIDRYSTPRMPWHDIGSVVHGKAARDVARHFIQRWNFTKIMKPKYRSLSYPFLLPKSQATAHELRYQVPGAVHAKAQLLRSAADWSAGIKHHEESIHAAYTHVIENSKHYIYIE NQFFISCADDKVVFNKVGNAIAQRILKAHREGQRYRVYIVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGESSILEQLKPELGNKWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIG SANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFAQGLRLECFRLVLGYLSDPSEDIQDPVSDKFFKEIWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPILAKEDRLRAEEELRKI RGFLVQFPFYFLSEENLLPSVGTKEAIVPMEVWT

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q9Z280}. Endoplasmic reticulum membrane {By SimilarityUniProtKB:Q9Z280}; Lipid-anchor {By SimilarityUniProtKB:Q9Z280}; Cytoplasmic side {By SimilarityUniProtKB:Q9Z280}. Golgi apparatus membrane {By SimilarityUniProtKB:Q9Z280}; Lipid-anchor {By SimilarityUniProtKB:Q9Z280}; Cytoplasmic side {By SimilarityUniProtKB:Q9Z280}. Late endosome membrane {By SimilarityUniProtKB:Q9Z280}; Lipid-anchor {By SimilarityUniProtKB:Q9Z280}; Cytoplasmic side {By SimilarityUniProtKB:Q9Z280}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	Curator Inference {ECO:0000305\|PubMed:11121416}
Assigned Ontology terms

Cellular Component	Apical Plasma Membrane (GO:0016324) Cholinergic Synapse (GO:0098981) Endocytic Vesicle (GO:0030139) Endoplasmic Reticulum Membrane (GO:0005789) Endosome (GO:0005768) Golgi Apparatus (GO:0005794) Golgi Cisterna (GO:0031985) Golgi Membrane (GO:0000139) Intracellular Membrane-Bounded Organelle (GO:0043231) Lamellipodium (GO:0030027) Late Endosome Membrane (GO:0031902) Perinuclear Region Of Cytoplasm (GO:0048471) Synapse (GO:0045202) Vesicle (GO:0031982)

Biology & Function

Description
Function as phospholipase selective for phosphatidylcholine (By similarity). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {By SimilarityUniProtKB:Q13393, By SimilarityUniProtKB:Q9Z280}.
Assigned Ontology terms

Biological Process	Defense Response To Gram-Positive Bacterium (GO:0050830) Inositol Lipid-Mediated Signaling (GO:0048017) Phosphatidic Acid Biosynthetic Process (GO:0006654) Phospholipid Biosynthetic Process (GO:0008654) Phospholipid Catabolic Process (GO:0009395) Positive Regulation Of Cell Migration (GO:0030335) Positive Regulation Of Translation (GO:0045727) Regulation Of Microvillus Assembly (GO:0032534) Regulation Of Synaptic Vesicle Cycle (GO:0098693) Regulation Of Vesicle-Mediated Transport (GO:0060627) Response To Peptide Hormone (GO:0043434)
Molecular Function	N-Acylphosphatidylethanolamine-Specific Phospholipase D Activity (GO:0070290) Phosphatidylinositol Binding (GO:0035091) Phospholipase D Activity (GO:0004630)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9Z2F5	C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) (50 kDa BFA-dependent ADP-ribosylation substrate) (BARS-50) (C-terminal-binding protein 3) (CtBP3)	EBI-8605013	0.40

Cross-References

Database	Links
UNIPROT	P70496 O08959 O35856 O54765 P70497 Q9QWJ6
Pfam	PF00169 PF00614 PF13091 PF00787
PROSITE	PS50003 PS50035 PS50195

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