NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

ADP-ribosylation factor 5 - Mus musculus - NucEnvDB

ADP-ribosylation factor 5 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	ADP-ribosylation factor 5
Accession Code	P84084
Gene	Arf5
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 180)
MGLTVSALFSRIFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVQESADELQKMLQEDELRDAVLLVFANKQDM PNAMPVSELTDKLGLQHLRSRTWYVQATCATQGTGLYDGLDWLSHELSKR

Subcellular Location

Description
Golgi apparatus. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P84085}. Membrane {By SimilarityUniProtKB:P84085}; Lipid-anchor {By SimilarityUniProtKB:P84085}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269\|PubMed:11950392}; Lipid-anchor {ECO:0000305}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250\|UniProtKB:P84085}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Golgi Apparatus (GO:0005794) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. {Experimental EvidencePubMed:11950392}.
Assigned Ontology terms

Biological Process	Intracellular Protein Transport (GO:0006886) Protein Transport (GO:0015031) Retrograde Vesicle-Mediated Transport, Golgi To Endoplasmic Reticulum (GO:0006890) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	GTP Binding (GO:0005525) GTPase Activity (GO:0003924)

Protein-Protein Interactions

Interactions with other proteins (6 interactors)

Partner (UniProt)		IntAct	Confidence score
P68510	14-3-3 protein eta	EBI-8586548	0.35
Q9JKK1	Syntaxin-6	EBI-7569455	0.27
Q8BYR5	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2)	EBI-7569528	0.60
F6SEU4	Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)	EBI-16733301	0.53
Q62108	Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)	EBI-16724752	0.35
Q9D415	Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)	EBI-16725590	0.35

Cross-References

Database	Links
UNIPROT	P84084 A2RTC5 P26437
Pfam	PF00025
PROSITE	PS51417

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