NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

DEAD-box ATP-dependent RNA helicase rde-12 - Caenorhabditis elegans - NucEnvDB

DEAD-box ATP-dependent RNA helicase rde-12 (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	DEAD-box ATP-dependent RNA helicase rde-12
Accession Code	P90897
Gene	rde
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 959)
MSSFGNNAGGGGREYHDDRSNRDHRHGNGGSDAGQRRREDHNSSYQSYRRPDGRQDSYGGGHQGNHGNSYGRREDDRSHSRDNHGGSRYGERDDRGNNGRSADNRYSQSNYNYDSNRGGQHYQRDNHGSK DDRGPMNQYNDHGSNHNSNSRNDQYRQGSYQGDGHSGYRRDDDRRRNDNDQARPYQSNRDSDRNSPRDHHNYNSQSSPRSHQGGQDRYSAPKEDNQRRYDNHQGGHDSYRGQNSGGYSGNNSGEYRNDYR SQQDSRDHRSGGNNSSSGFKNDGGFGGNDNRGFGNNGGGSFGNPNNSYRGNSNNIGGFHRSDGSNSEGVNAPVRAPRDWVPVTRDIDELVRETADRLADCDVGQDRAVEIRNAEKDVRLTSWTNSGLHPT ILETLKRIKYNNVRTIQGAMIPQVLDGHDVLGQAETSAGKTAAFGLPIIDKILRMDEETRNKARQDDGPLALILAPTRELAAQIHEALRTYCQNTDIIVLLSYGQSDRARSLNEIRNGCDILIGTCGRIM DFTVKSHISLLHLRFLVFDEADRLLQDMKKDPLGHLGAIIKDAGFMESAATRQTIMTSATFNASVMTVANELMKRLPGQDEMIKIVLANGRLSKRVNLEFFECKGLAEKNAKLREILKQNVNGKTLKTII FVQKKDQCDACAAKLTSGGMLAQTLHGDRSQDMREKLINDFKSNRVNLLVTTDLLSRGIDVSDLDRVINFDLPDGDPDQGADTFIHRAGRTGRTGRKENGLCVSFVDPQSDRDSLLAPKLVELIISQNLP DLKVPDFLDAMAKSSRGKSGTSGFGQRGGYGGRGGGFGGTGRGRGGGVFGGGGRGGDFGGSGNFGGSGGGGSFGGSGGGGGFGGVKPSGFGGSRNNAEPTSSGGGFGAPKAPTGFPSDNNDASEDAPAAG GFGFSTKAAQDAKKAEESATLGSSTFGTANNADEEPTETGADGNDDDEW

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:24684931}. Cytoplasmic granule {Experimental EvidencePubMed:24684930, Experimental EvidencePubMed:24684931}. Cytoplasm {Experimental EvidencePubMed:24684931}. Cytoplasm, P-body {Experimental EvidencePubMed:24684930}. Note=Colocalizes with pgl-1 in perinuclear P granules. Colocalizes with rsd-6 in a subset of germline and embryonic foci. {Experimental EvidencePubMed:24684930}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nucleus (GO:0005634) P Granule (GO:0043186) P-Body (GO:0000932) Perinuclear Region Of Cytoplasm (GO:0048471) RNAi Effector Complex (GO:0031332)

Biology & Function

Description
Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing (PubMed:24684930, PubMed:24684931). Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs (PubMed:24684930, PubMed:24684931). May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis (PubMed:24684930). May be recruited to target mRNAs by rde-1 and/or ergo-1 (PubMed:24684930, PubMed:24684931). {Experimental EvidencePubMed:24684930, Experimental EvidencePubMed:24684931}.
Assigned Ontology terms

Biological Process	Cell Differentiation (GO:0030154) Gamete Generation (GO:0007276) Regulation Of Translation (GO:0006417) Response To Exogenous DsRNA (GO:0043330) SiRNA Processing (GO:0030422)
Molecular Function	ATP Binding (GO:0005524) ATP Hydrolysis Activity (GO:0016887) Enzyme Binding (GO:0019899) RNA Binding (GO:0003723) RNA Helicase Activity (GO:0003724)

Cross-References

Database	Links
UNIPROT	P90897 G3MU56 G3MU57
Pfam	PF00270 PF00271
PROSITE	PS00039 PS51192 PS51194 PS51195

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