National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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| Protein Name | Focal adhesion kinase 1 |
| Accession Code | Q00944 |
| Gene | PTK2 |
| Organism | Gallus gallus | Chicken (Taxonomy: 9031) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 1053) |
Structure Viewer (PDB: 2AL6) |
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Description |
Position in the Nuclear Envelope |
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| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Peripheral | UniProt | Experimental Evidence {ECO:0000269|PubMed:8423801} | Assigned Ontology terms |
Description |
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| Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. {Experimental EvidencePubMed:15494732, Experimental EvidencePubMed:15494733, Experimental EvidencePubMed:15494734, Experimental EvidencePubMed:20705914, Experimental EvidencePubMed:21852560, Experimental EvidencePubMed:21937583}. | Assigned Ontology terms |
Interactions with Nuclear Envelope proteins (3 interactors) |
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Interactions with other proteins (9 interactors) |
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Database | Links |
| UNIPROT | Q00944 |
| PDB | 1KTM 1PV3 1QVX 2AEH 2AL6 2J0J 2J0K 2J0L 2J0M 2JKK 2JKM 2JKO 2JKQ 2L6F 2L6G 2L6H 3ZDT 4BRX 4C7T 4CYE 4D4R 4D4S 4D4V 4D4Y 4D55 4D58 4D5H 4D5K 6CB0 6GCR 6GCW 6GCX 6TY3 6TY4 |
| Pfam | PF00373 PF18038 PF03623 PF07714 |
| PROSITE | PS00661 PS50057 PS00107 PS50011 PS00109 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory