NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Inactive diphosphatase DCS2 - Saccharomyces cerevisiae S288C - NucEnvDB

Inactive diphosphatase DCS2 (Saccharomyces cerevisiae S288C)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Inactive diphosphatase DCS2
Accession Code	Q12123
Gene	DCS2
Organism	Saccharomyces cerevisiae S288C (Taxonomy: 559292)
Part of Reference Proteome?	Yes
Sequence (Length: 353)
MGSQDLASLIGRFKYVRVLDSNPHTKVISLLGSIDGKDAVLTAEKTHFIFDETVRRPSQSGRSTPIFFHREIDEYSFLNGITDLKELTSNDIYYWGLSVLKQHILHNPTAKVNLIWPASQFHIKGYDQQD LHVVRETPDMYRNIVVPFIQEMCTSERMKWVNNILYEGAEDDRVVYKEYSSRNKEDGFVILPDMKWDGINIDSLYLVAIVYRDDIKSLRDLNPNHRDWLIRLNKKIKTIIPQHYDYNVNPDELRVFIHYQ PSYYHFHVHIVNIRHPGVGEERGSGMTILLEDVIEALGFLGPEGYMKKTLTYVIGENHDLWKKGFKEEVEKQLKHDGIATSPEKGSGFNTNLG

Subcellular Location

Description
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, P-body. Note=Predominantly cytoplasmic. Localizes close to the perinuclear space before the diauxic growth shift. Recruited to the P-body after the post-diauxic growth shift. Colocalizes with the decapping activator protein LSM1 at P-body.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nucleus (GO:0005634) P-Body (GO:0000932) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Plays a role in the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Stress-induced regulatory protein that modulates the m7GpppX diphosphatase activity of DCS1. {Experimental EvidencePubMed:15240832, Experimental EvidencePubMed:16963086}.
Assigned Ontology terms

Biological Process	Cellular Response To Nutrient (GO:0031670) Cellular Response To Starvation (GO:0009267) Deadenylation-Dependent Decapping Of Nuclear-Transcribed MRNA (GO:0000290) Nuclear-Transcribed MRNA Catabolic Process (GO:0000956) Nuclear-Transcribed MRNA Catabolic Process, Nonsense-Mediated Decay (GO:0000184) Regulation Of M7G(5')PppN Diphosphatase Activity (GO:1903398) Response To Heat (GO:0009408) Response To Nutrient (GO:0007584) Response To Osmotic Stress (GO:0006970) Response To Oxidative Stress (GO:0006979)
Molecular Function	Enzyme Inhibitor Activity (GO:0004857) M7G(5')PppN Diphosphatase Activity (GO:0050072) Protein Heterodimerization Activity (GO:0046982) Protein Homodimerization Activity (GO:0042803) RNA 7-Methylguanosine Cap Binding (GO:0000340)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q12123	Self	EBI-21322203	0.37
Q06151	m7GpppX diphosphatase	EBI-786407	0.87
Interactions with other proteins (10 interactors)

Partner (UniProt)		IntAct	Confidence score
P37366	Cyclin CCL1	EBI-791370	0.53
Q06218	ATP-dependent RNA helicase DBP9 (EC 3.6.4.13) (DEAD box protein 9)	EBI-816740	0.27
P40024	ABC transporter ATP-binding protein ARB1 (ATP-binding cassette protein involved in ribosome biogenesis 1)	EBI-817974	0.27
Q08004	Bud site selection protein 20	EBI-819653	0.27
P07245	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]	EBI-821183	0.27
P38829	MIP18 family protein YHR122W	EBI-855499	0.00
Q12179	Uncharacterized protein YPL245W	EBI-7886118	0.40
P47035	Nucleolar protein NET1	EBI-7998776	0.40
P11484	Ribosome-associated molecular chaperone SSB1 (EC 3.6.4.10) (Cold-inducible protein YG101) (Heat shock protein SSB1) (Hsp70 chaperone Ssb)	EBI-3687179	0.35
P14680	Dual specificity protein kinase YAK1 (EC 2.7.12.1)	EBI-16286565	0.35

Cross-References

Database	Links
UNIPROT	Q12123 D6W2M9
Pfam	PF05652
PROSITE	PS00892

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