NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein spire homolog 1 - Danio rerio - NucEnvDB

Protein spire homolog 1 (Danio rerio)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Protein spire homolog 1
Accession Code	Q1LYM3
Gene	spire1
Organism	Danio rerio \| Zebrafish (Taxonomy: 7955)
Part of Reference Proteome?	Yes
Sequence (Length: 761)
MTDGGMLISPSALQDPGDGARPEDIAMDCTDGEEELCLEEILTLYSQPINEEQAWAVCYQCCRWLTQKHRRKETGVSPPGRIAGPGDVRIRKDGNVKLYQPSNPDKHTPPSSSIEIIESLGIMIYKALDY GLKEHEERELSPPLEQLIDLMTNMADTETDCPDEGYEATEEEDEGEEENAEVSNVRGYRDIISLCLSHLPSPSDAPNHYQAVCRALYAETKELRTFLEKIKSAKENLRKMEGETEEPVRDLNELQNADWA RFWVQVMRDLRHGVKLKKVQERQYNPLAIEYQLTPYEMLMDDIRSKRYKLRKVMVNGDIPPRLKKSAHEIILEFIRSRPPLNPVSARKLKPHAPQPPTLHERILEEIRSERKLRPVSPDMIRRSRLGAGK SISTPQDLFRSSDIPDGPRKLAISTLSLANGTSPARSPVNGVAGGHSLSQRKRLLKAPTLAELDSSDSEEEQSTRKSDSSSSISTSLVEDTSPESVMGKKPPPQFLPISSTPQPDKRIAPQRRHSIEKEA PTNIRHFLPPSRQNSKSLAHALGSGHAEEFCFPVECLTLTVEEVMHIRQVLVKAELEKFQQYKDIYNALKKGKLCFSCRSKKFSLFTWSYTCQFCKRPVCSQCCKKMKLPSKPHASLPISSLGPSILPKK EPGASSAPTDKTSSTSSHKKNSLQRSLSRSSKHGDRSSSKDELELPEQFTEDWSTMEVCVDCKKFINDIISNSRRNLSTKRARLHRRTHSVYSSSTSSSNYKPTERTIKEV

Subcellular Location

Description
Cytoplasm, cytoskeleton {By SimilarityUniProtKB:Q52KF3}. Cytoplasm, cytosol {By SimilarityUniProtKB:Q52KF3}. Cleavage furrow {By SimilarityUniProtKB:Q52KF3}. Cytoplasm, perinuclear region {ECO:0000250\|UniProtKB:Q08AE8}. Cell membrane {By SimilarityUniProtKB:Q52KF3}; Peripheral membrane protein {By SimilarityUniProtKB:Q52KF3}; Cytoplasmic side {By SimilarityUniProtKB:Q52KF3}. Cytoplasmic vesicle membrane {By SimilarityUniProtKB:Q52KF3}; Peripheral membrane protein {By SimilarityUniProtKB:Q52KF3}; Cytoplasmic side {By SimilarityUniProtKB:Q52KF3}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:Q52KF3}
Assigned Ontology terms

Cellular Component	Cell Cortex (GO:0005938) Cleavage Furrow (GO:0032154) Cytoplasmic Vesicle Membrane (GO:0030659) Cytoskeleton (GO:0005856) Cytosol (GO:0005829) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. In addition, promotes innate immune signaling downstream of dsRNA sensing. Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1. {By SimilarityUniProtKB:Q08AE8}.
Assigned Ontology terms

Biological Process	Actin Filament Network Formation (GO:0051639) Actin Filament Polymerization (GO:0030041) Actin Nucleation (GO:0045010) Cleavage Furrow Formation (GO:0036089) Establishment Of Meiotic Spindle Localization (GO:0051295) Formin-Nucleated Actin Cable Assembly (GO:0070649) Golgi Vesicle Transport (GO:0048193) Intracellular Transport (GO:0046907) Polar Body Extrusion After Meiotic Divisions (GO:0040038) Positive Regulation Of Double-Strand Break Repair (GO:2000781) Protein Transport (GO:0015031)
Molecular Function	Actin Binding (GO:0003779)

Cross-References

Database	Links
UNIPROT	Q1LYM3 Q08BK5
Pfam	PF16474
PROSITE	PS51377

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