NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

E3 ubiquitin-protein ligase SH3RF1 - Xenopus tropicalis - NucEnvDB

E3 ubiquitin-protein ligase SH3RF1 (Xenopus tropicalis)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	E3 ubiquitin-protein ligase SH3RF1
Accession Code	Q28E95
Gene	sh3rf1
Organism	Xenopus tropicalis \| Tropical clawed frog (Taxonomy: 8364)
Part of Reference Proteome?	Yes
Sequence (Length: 861)
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVSSRNELRCPECRTLVECGVDELPSNILLVRLLDGIKQRPRKAGVGGSAGNSTNVLRAQGSLTTNCGLNDAQNIHGGQQRIQARSPPVRG VPQLPCAKALYNYEGKEPGDLKFNKGDIIVLRRQVDENWYHGEINGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFLKDDILTVIRRVDENWAEGMLGDKIGIFPISYVEFNSAAKQ LIELDKPSGVDTGEGSSGTTHSSNSQKQADAKKNTKKRHSFTSLTMSNKSSQSVQNRHSMEISPPVLISSSNPTAAARISELTGLSCSAPSQVHISTTGLIVTPPPSSPVVSGPAFTFPPEVTYQAALGD LNPPLLPPPPLATPVITSTSSGAAAAVQRSISGPAEQVTHLRTSTRPSVFVAIYPYIPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRALTTATPAKVAMATASSSNVVNLV TPTPPGAPCQKLQGNGAEFAKTVSTNGVPPAGIPGSHIQSSPQAKVLLHMSGQMTVNQARNAVRTAAAHSQDRPTAAVTPIQAQIPSASVLPQQAATSQQMPPPLSGPAAYINAAMNISRPSVPVASAAS SSVSSAAFETECNWKSGSGLAACSFPENVSAPLNSAANKQDKDSKKEKKGLLKLLSGASTKRKPRSSPPHSPTQELEQTNSEAALEGAVGPDILPVNGNGRVASCTVDCDLVSASALVQDNRKPASLDTN VPIAPPPRQPCSSLGTVLNDSRPCERYRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q71F54}. Cell projection, lamellipodium {By SimilarityUniProtKB:Q69ZI1}. Golgi apparatus, trans-Golgi network {By SimilarityUniProtKB:Q69ZI1}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Golgi Apparatus (GO:0005794) Lamellipodium (GO:0030027) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway. {By SimilarityUniProtKB:Q69ZI1, By SimilarityUniProtKB:Q6NRD3, By SimilarityUniProtKB:Q7Z6J0}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Apoptotic Process (GO:0043066) Neuron Migration (GO:0001764) Positive Regulation Of JNK Cascade (GO:0046330) Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process (GO:0032436) Protein Autoubiquitination (GO:0051865) Protein Ubiquitination (GO:0016567) Regulation Of CD4-Positive, Alpha-Beta T Cell Differentiation (GO:0043370) Regulation Of CD8-Positive, Alpha-Beta T Cell Proliferation (GO:2000564)
Molecular Function	MAP-Kinase Scaffold Activity (GO:0005078) Metal Ion Binding (GO:0046872) Ubiquitin Protein Ligase Activity (GO:0061630)

Cross-References

Database	Links
UNIPROT	Q28E95
Pfam	PF00018 PF14604 PF00097
PROSITE	PS50002 PS00518 PS50089

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