National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | PAK-2p34 |
| Accession Code | Q29502 |
| Gene | PAK2 |
| Organism | Oryctolagus cuniculus | Rabbit (Taxonomy: 9986) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 524) |
Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Lipid-Anchored | UniProt | By Similarity {ECO:0000250|UniProtKB:Q13177} | Assigned Ontology terms |
Description |
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|---|---|
| Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Phosphorylates CASP7, thereby preventing its activity. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity). {By SimilarityUniProtKB:Q13177}. | Assigned Ontology terms |
Interactions with Nuclear Envelope proteins (1 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | Q29502 |
| Pfam | PF00786 PF00069 |
| PROSITE | PS50108 PS00107 PS50011 PS00108 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory