NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Arachidonate 12-lipoxygenase, 12R-type - Rattus norvegicus - NucEnvDB

Arachidonate 12-lipoxygenase, 12R-type (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Arachidonate 12-lipoxygenase, 12R-type
Accession Code	Q2KMM4
Gene	Alox12b
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 701)
MATYKVKVATGTDFFSGTLDSISLTIVGTQGESHKQRLNHFGRDFATGAVDDYTVQCQQDLGELIIIRLHKEPHSFLPKDPWYCNYVQICAPNCRVYHFPAYQWMDGYETLSLREATGKTTADDTLPILL EHRQEEIRAKKDFYHWRVFVPGLPNYVDIPSYHPPPRRCRNPNRPEWNGYIPGFPILINIKATRFLNLNLRFSFVKTASFFYRLGPMALAFKLRGLVDRKRSWKRLKDIKNIFPATKTVVSEYVAEHWTE DSFFGYQYLNGINPGHIRRCMQIPDKFPVTDEMVAPFLGEGTCLQAELEKGNIYLADYRILDGIPTVELNGQKQHHCAPICLLHFGPDGNMMPIAIQLSQTPGPDCPIFLPNDSEWDWLLAKTWVRYAEF YSHEAVAHLLESHLIGEAFCLALLRNLPMCHPLYKLLIPHTRYNVQINSIGRALLLNKGGLSARAMSLGLEGFAQVMVRGLSELTYKSLCIPNDFVERGVQDLPGYYFRDDSLAVWYAMERYVTEIITYY YPNDAAVEGDPELQCWVQEIFKECLLERESSGFPTCLRTVPELIEYVTMVMYTCSARHAAVNTGQLEYTSWMPNFPSSMRNPPMQSKGLTTLQTFMDTLPDVKTTCIVLLVLWTLCREPDDRRPLGHFPD IHFVEEAPRRSMEAFRQNLNQISHNIRQRNKCLNLPYYYLDPVLIENSISI

Subcellular Location

Description
Cytoplasm {Sequence AnalysisPROSITE-ProRule:PRU00726}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:O75342}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:23382512). In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega- hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins (By similarity). {By SimilarityUniProtKB:O75342, Experimental EvidencePubMed:23382512}.
Assigned Ontology terms

Biological Process	Arachidonic Acid Metabolic Process (GO:0019369) Ceramide Biosynthetic Process (GO:0046513) Establishment Of Skin Barrier (GO:0061436) Hepoxilin Biosynthetic Process (GO:0051122) Linoleic Acid Metabolic Process (GO:0043651) Lipid Oxidation (GO:0034440) Lipoxygenase Pathway (GO:0019372) Positive Regulation Of Gene Expression (GO:0010628) Positive Regulation Of MAPK Cascade (GO:0043410) Positive Regulation Of Mucus Secretion (GO:0070257) Protein Lipidation (GO:0006497) Sphingolipid Metabolic Process (GO:0006665)
Molecular Function	Arachidonate 12(R)-Lipoxygenase Activity (GO:0106237) Arachidonate 12(S)-Lipoxygenase Activity (GO:0004052) Arachidonate 8(R)-Lipoxygenase Activity (GO:0047677) Iron Ion Binding (GO:0005506) Linoleate 9S-Lipoxygenase Activity (GO:1990136) Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen (GO:0016702)

Cross-References

Database	Links
UNIPROT	Q2KMM4 Q2KMM5
Pfam	PF00305 PF01477
PROSITE	PS00711 PS00081 PS51393 PS50095

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