NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog - Mus musculus - NucEnvDB

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog
Accession Code	Q2TBA3
Gene	Malt1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 832)
MSLWGQPLQASPPLAVRQPPTASSGPSTSPPAGATLNRLPEPLLRRLSESLDRAPEGRGWRQLAELAGSRGRLRLSGLDL EQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQALEHTEVLPLLNPPGLKITVNPESKAVLAGQFVKLCCRATGHP FVQYQWFKMNKEIPYGNSSELVFNTVHVKDAGFYVCRVNNSSTFEFSQWSQLDVCDVAEVTDSFQGSMDGISESRLQICV EPRSQRLVPGSMLLLQCVAIGSPMPHYQWFKDESPLTHETKKHYTVPYVDIEHEGTYWCHVYNDRDSQDSKKAEVTIGRT DEAVECTEDELNNLGHPDNKEQTGQPLAKDKVALLIGNMSYWEHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMC NAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDD TIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGRQALEIRS SLSEKRALTDPVQGAPCSAEALVRNLQWAKAHELPESMCLKFQCGVHIQLGFAAEFSNVMIIYTSIVHKPPEIIMCDAYV TDFPLDLDIDPKHANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLIFTVCLSYQYSGLEDTVEEKQEVNVGKPLI AKLDMHRGLGRKTCFQACRMPDEPYHSSTSTSAGAGHFHSSQDSFHDVYHSHLGNADSGMPPDRCHCSRTPHTFISNYPP HHYCQFGRSNVPVETTDEMPFSFSDRLMISEN

Structure Viewer (PDB: 3V4L)

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q9UDY8}. Nucleus {By SimilarityUniProtKB:Q9UDY8}. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10 (By similarity). {By SimilarityUniProtKB:Q9UDY8}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	CBM Complex (GO:0032449) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Fibrillar Center (GO:0001650) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Polkadots (GO:0002096) Protein-Containing Complex (GO:0032991)

Biology & Function

Description
Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor- induced integrin adhesion (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation (By similarity). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (PubMed:25282160). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (By similarity). {By SimilarityUniProtKB:Q9UDY8, Experimental EvidencePubMed:25282160}.
Assigned Ontology terms

Biological Process	Activation Of NF-KappaB-Inducing Kinase Activity (GO:0007250) B Cell Activation (GO:0042113) B-1 B Cell Differentiation (GO:0001923) Cellular Response To Lipopolysaccharide (GO:0071222) Innate Immune Response (GO:0045087) Lipopolysaccharide-Mediated Signaling Pathway (GO:0031663) Nuclear Export (GO:0051168) Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process (GO:0043280) Positive Regulation Of Interleukin-1 Beta Production (GO:0032731) Positive Regulation Of Interleukin-2 Production (GO:0032743) Positive Regulation Of NF-KappaB Transcription Factor Activity (GO:0051092) Positive Regulation Of T Cell Activation (GO:0050870) Positive Regulation Of T Cell Cytokine Production (GO:0002726) Positive Regulation Of T-Helper 17 Cell Differentiation (GO:2000321) Proteolysis (GO:0006508) Proteolysis Involved In Protein Catabolic Process (GO:0051603) Regulation Of Apoptotic Process (GO:0042981) Regulation Of T Cell Receptor Signaling Pathway (GO:0050856) Response To Fungus (GO:0009620) T Cell Proliferation (GO:0042098) T Cell Receptor Signaling Pathway (GO:0050852)
Molecular Function	Cysteine-Type Endopeptidase Activity (GO:0004197) Endopeptidase Activity (GO:0004175) Identical Protein Binding (GO:0042802) Kinase Activator Activity (GO:0019209) Peptidase Activity (GO:0008233) Protease Binding (GO:0002020) Protein Self-Association (GO:0043621) Ubiquitin-Protein Transferase Activity (GO:0004842)

Protein-Protein Interactions

Interactions with other proteins (3 interactors)

Partner (UniProt)		IntAct	Confidence score
P47741	Tumor necrosis factor receptor superfamily member 4 (OX40 antigen) (OX40L receptor) (CD antigen CD134)	EBI-15909866	0.35
Q60855	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)	EBI-15909932	0.35
Q60803	TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (RING-type E3 ubiquitin transferase TRAF3)	EBI-16718608	0.40

Cross-References

Database	Links
UNIPROT	Q2TBA3 Q2TBA2 Q811E3 Q8BFT0 Q8C7N9
PDB	3V4L
Pfam	PF13895 PF18703
PROSITE	PS50208 PS50835

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