NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein kinase C-binding protein NELL1 - Mus musculus - NucEnvDB

Protein kinase C-binding protein NELL1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Protein kinase C-binding protein NELL1
Accession Code	Q2VWQ2
Gene	Nell1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 810)
MPMDVILVLWFCVCTARTVLGFGMDPDLQMDIITELDLVNTTLGVTQVAGLHNASKAFLFQDVQREIHSAPHVSEKLIQLFRNKSEFTFLATVQQKPSTSGVILSIRELEHSYFELESSGPREEIRYHYI HGGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPETNLPPGSNLWLGQRNQKHGFFKGIIQDGKIIFMPNGFITQCPNLNRTCPTCSDFLSLVQGIMDLQELLAKMTAKLNYAETR LGQLENCHCEKTCQVSGLLYRDQDSWVDGDNCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHISGQCCKVCRPKCIYGGKVLAEGQRILTKTCRECRGGVLVKITEACPPLNCSEKDHILPENQCCRVCR GHNFCAEAPKCGENSECKNWNTKATCECKNGYISVQGNSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCIPGYIRVDDFSCTEHDDCGSGQHNCDKNAICTNTVQGHSCTCQPGYVGNGTVCKAFCE EGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECAEGFVECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWILR EDRCSVCSCKDGKIFCRRTACDCQNPNVDLFCCPECDTRVTSQCLDQSGQKLYRSGDNWTHSCQQCRCLEGEADCWPLACPSLSCEYTAIFEGECCPRCVSDPCLADNIAYDIRKTCLDSSGISRLSGAV WTMAGSPCTTCQCKNGRVCCSVDLVCLENN

Subcellular Location

Description
Cytoplasm {By Similarity}. Nucleus envelope {By Similarity}. Secreted {By Similarity}. Note=Colocalizes with ATRAID on the nuclear envelope and the perinuclear region. {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Extracellular Space (GO:0005615) Nuclear Envelope (GO:0005635) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. {Experimental EvidencePubMed:16537572}.
Assigned Ontology terms

Biological Process	Cell Differentiation (GO:0030154) Negative Regulation Of Osteoblast Proliferation (GO:0033689) Negative Regulation Of Protein Catabolic Process (GO:0042177) Positive Regulation Of Apoptotic Process (GO:0043065) Positive Regulation Of Bone Mineralization (GO:0030501) Positive Regulation Of Ossification (GO:0045778) Positive Regulation Of Osteoblast Differentiation (GO:0045669) Regulation Of Gene Expression (GO:0010468) Regulation Of Osteoblast Differentiation (GO:0045667)
Molecular Function	Calcium Ion Binding (GO:0005509) Heparin Binding (GO:0008201) Identical Protein Binding (GO:0042802) Protein Kinase C Binding (GO:0005080)

Cross-References

Database	Links
UNIPROT	Q2VWQ2
Pfam	PF12947 PF07645 PF02210 PF00093
PROSITE	PS00010 PS00022 PS01186 PS50026 PS01187 PS50025 PS01208 PS50184

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