NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Transmembrane protein 184A - Mus musculus - NucEnvDB

Transmembrane protein 184A (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Transmembrane protein 184A
Accession Code	Q3UFJ6
Gene	Tmem184a
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 425)
MRNASGFLKTAGAPLVSATWLPPSPPPAMPTVAAGPQMERVDNGSQGAPQLFLTSALARGVSGVFVWTALLLTGHQIYSHLRSYTAPREQRFVIRLLFIVPIYAFDSWLSLLLLGGHPYYVYFDSVRDCY EAFVIYSFLTLCFQYLGGESAIMAEIRGKPIRSSCFYGTCCLRGMSYSITFLRFCKQATLQFCIVKPVMALITIILQAFDKYHDGDFNIHSGYLYVTLVYNASVSLALYALFLFYFATRDLLRPFEPVLK FLTIKAIIFLSFWQGMLLAILERCGVIPEVQAVDGTRVGAGTLAAGYQNFLICVEMLFASLALRYAFPSQVYSEKKNSPVPPAPMQSISSGLKETISPQDIVQDAIHNFSPAYQQYTQQSTHEAPGPGQG GHPAPSTHPGPASGSGGGKKSRNIEKRMLIPSEDL

Subcellular Location

Description
Cell membrane {By SimilarityUniProtKB:Q1RMW2}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q1RMW2}. Cytoplasmic vesicle membrane {By SimilarityUniProtKB:Q1RMW2}; Multi-pass membrane protein {Sequence Analysis}. Early endosome membrane {ECO:0000269\|PubMed:18321981}; Multi-pass membrane protein {ECO:0000305}. Endosome {ECO:0000269\|PubMed:18321981, ECO:0000269\|PubMed:19097053}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269\|PubMed:19097053}. Note=Colocalizes with the secretory granule marker VAMP2 in pancreatic acinar cells (PubMed:19097053). {ECO:0000269\|PubMed:19097053}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cytoplasmic Vesicle Membrane (GO:0030659) Early Endosome Membrane (GO:0031901) Endosome (GO:0005768) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Secretory Granule Membrane (GO:0030667) Transport Vesicle Membrane (GO:0030658)

Biology & Function

Description
Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (PubMed:18321981, PubMed:19097053). {By SimilarityUniProtKB:Q4QQS1, Experimental EvidencePubMed:18321981, Experimental EvidencePubMed:19097053}.
Assigned Ontology terms

Biological Process	Germ-Line Sex Determination (GO:0018992) Regulation Of Protein Localization (GO:0032880) Regulation Of Secretion (GO:0051046)
Molecular Function	Heparin Binding (GO:0008201)

Cross-References

Database	Links
UNIPROT	Q3UFJ6 Q8BII8 Q8K1B0
Pfam	PF03619

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