NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein NDRG2 - Bos taurus - NucEnvDB

Protein NDRG2 (Bos taurus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Protein NDRG2
Accession Code	Q3ZBA8
Gene	NDRG2
Organism	Bos taurus \| Cattle (Taxonomy: 9913)
Part of Reference Proteome?	Yes
Sequence (Length: 357)
MAELREVQITEEKPLLPGQTPEVAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFADMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGIG VGAGAYVLSRYALTHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSISEMILGHLFSQEELSGNSELIQKYRNIIAHAPNLDNIELYWNSYNNRRDLNFVRGGDTTLKCPVMLVVGDQAPHEDAVVEC NSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC

Subcellular Location

Description
Cytoplasm {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Cell projection, growth cone {By Similarity}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Golgi Apparatus (GO:0005794) Growth Cone (GO:0030426) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Cell Differentiation (GO:0030154) Negative Regulation Of Cytokine Production (GO:0001818) Negative Regulation Of ERK1 And ERK2 Cascade (GO:0070373) Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation (GO:1904706) Nervous System Development (GO:0007399) Regulation Of Platelet-Derived Growth Factor Production (GO:0090361) Regulation Of Vascular Endothelial Growth Factor Production (GO:0010574) Signal Transduction (GO:0007165) Vascular Associated Smooth Muscle Cell Proliferation (GO:1990874) Wnt Signaling Pathway (GO:0016055)
Molecular Function

Cross-References

Database	Links
UNIPROT	Q3ZBA8
Pfam	PF03096

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