NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Transmembrane protein 184A - Rattus norvegicus - NucEnvDB

Transmembrane protein 184A (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Transmembrane protein 184A
Accession Code	Q4QQS1
Gene	Tmem184a
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 425)
MRNASGFLKTAGAPLVSATWLPPSPPPAMPMVAAGPQMERVDNGSQGAPQLFLTSALARGVSGVFVWTALLLTGHQIYSHLRSYTVPREQRFVIRLLFIVPIYAFDSWLSLLLLGGHPYYVYFDSVRDCY EAFVIYSFLTLCFQYLGGESAIMAEIRGKPIRSSCFYGTCCLRGMSYSITFLRFCKQATLQFCIVKPVMALITIILQAFDKYHDGDFNIHSGYLYVTLVYNASVSLALYALFLFYFATRDLLRPFEPVLK FLTIKAIIFLSFWQGMLLAILERCGVIPEVQAVDGTRVGAGTLAAGYQNFLICIEMLFASLALRYAFPSQVYSEKKNSPAPPAPMQSISSGLKETISPQDIVQDAIHNFSPAYQQYTQQSTHEAPGPGQG GHPSPSTHPGPASGSGGGKKSRNIEKRMLIPSEDL

Subcellular Location

Description
Cell membrane {Experimental EvidencePubMed:26769966}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:26769966}. Early endosome membrane {By SimilarityUniProtKB:Q3UFJ6}; Multi-pass membrane protein {Curator Inference}. Endosome {By SimilarityUniProtKB:Q3UFJ6}. Cytoplasmic vesicle, secretory vesicle membrane {By SimilarityUniProtKB:Q3UFJ6}. Cytoplasmic vesicle membrane {ECO:0000250\|UniProtKB:Q1RMW2}; Multi-pass membrane protein {Sequence Analysis}. Note=Colocalizes with CAV1 (PubMed:26769966). {Experimental EvidencePubMed:26769966}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cytoplasmic Vesicle Membrane (GO:0030659) Early Endosome Membrane (GO:0031901) Endosome (GO:0005768) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Secretory Granule Membrane (GO:0030667) Transport Vesicle Membrane (GO:0030658)

Biology & Function

Description
Acts as a heparin receptor in vascular cells (PubMed:26769966). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity). {By SimilarityUniProtKB:Q3UFJ6, Experimental EvidencePubMed:26769966}.
Assigned Ontology terms

Biological Process	Germ-Line Sex Determination (GO:0018992) Regulation Of Protein Localization (GO:0032880) Regulation Of Secretion (GO:0051046)
Molecular Function	Heparin Binding (GO:0008201)

Cross-References

Database	Links
UNIPROT	Q4QQS1 Q5XHY9
Pfam	PF03619

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