NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Echinoderm microtubule-associated protein-like 1 - Rattus norvegicus - NucEnvDB

Echinoderm microtubule-associated protein-like 1 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Echinoderm microtubule-associated protein-like 1
Accession Code	Q4V8C3
Gene	Eml1
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 814)
MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEISDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLGQTLPLRTTVNNGTVLPKKPSASLPSPSGSRKEMVVPVTKSIN RTSSSERVSPGGRRESSGDSKGSRNRTGSTSSSSSGKKNSESKPKEPTFSPEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKAELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEE QLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGSHLCAVDDSNDHVLSVWDWQREERLADVKCSNEAVFAADFHPTDTNIIVTCG KSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKAEIPEQFGPIRTVAEGKGNVILIGT TRNFVLQGTLTGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIY IYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYS GHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q05BC3}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q05BC3}. Cytoplasm, cytoskeleton {By SimilarityUniProtKB:Q05BC3}. Note=Detected in cytoplasmic punctae. Co-localizes with microtubules. Enriched in perinuclear regions during interphase and in the region of spindle microtubules during metaphase. Enriched at the midzone during telophase and cytokinesis. Detected at growth cones in neurons. {By SimilarityUniProtKB:Q05BC3}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Microtubule (GO:0005874) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. {By SimilarityUniProtKB:Q05BC3}.
Assigned Ontology terms

Biological Process	Brain Development (GO:0007420) Hematopoietic Progenitor Cell Differentiation (GO:0002244) Microtubule Cytoskeleton Organization (GO:0000226) Mitotic Spindle Organization (GO:0007052) Neuroblast Proliferation (GO:0007405)
Molecular Function	Microtubule Binding (GO:0008017) Tubulin Binding (GO:0015631)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
P54645	5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)	EBI-16399805	0.35

Cross-References

Database	Links
UNIPROT	Q4V8C3
Pfam	PF03451 PF00400
PROSITE	PS00678 PS50082 PS50294

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