NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

DnaJ homolog subfamily A member 1 - Bos taurus - NucEnvDB

DnaJ homolog subfamily A member 1 (Bos taurus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	DnaJ homolog subfamily A member 1
Accession Code	Q5E954
Gene	DNAJA1
Organism	Bos taurus \| Cattle (Taxonomy: 9913)
Part of Reference Proteome?	Yes
Sequence (Length: 397)
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLTVTLEDLYNGATRKLALQK NVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFM CMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRG GVQCQTS

Subcellular Location

Description
Membrane {By Similarity}; Lipid-anchor {By Similarity}. Cytoplasm {By Similarity}. Microsome {By Similarity}. Mitochondrion {By Similarity}. Nucleus {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria (By similarity). {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Endoplasmic Reticulum (GO:0005783) Membrane (GO:0016020) Mitochondrion (GO:0005739) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Androgen Receptor Signaling Pathway (GO:0030521) Flagellated Sperm Motility (GO:0030317) Negative Regulation Of Apoptotic Process (GO:0043066) Negative Regulation Of JUN Kinase Activity (GO:0043508) Positive Regulation Of Apoptotic Process (GO:0043065) Protein Localization To Mitochondrion (GO:0070585) Protein Refolding (GO:0042026) Regulation Of Protein Transport (GO:0051223) Response To Heat (GO:0009408) Spermatogenesis (GO:0007283)
Molecular Function	ATP Binding (GO:0005524) ATPase Activator Activity (GO:0001671) Chaperone Binding (GO:0051087) Hsp70 Protein Binding (GO:0030544) Low-Density Lipoprotein Particle Receptor Binding (GO:0050750) Metal Ion Binding (GO:0046872) Unfolded Protein Binding (GO:0051082)

Cross-References

Database	Links
UNIPROT	Q5E954 Q3SZU2
Pfam	PF00226 PF01556 PF00684
PROSITE	PS00636 PS50076 PS51188

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