National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | DnaJ homolog subfamily A member 1 |
| Accession Code | Q5NVI9 |
| Gene | DNAJA1 |
| Organism | Pongo abelii | Sumatran orangutan (Taxonomy: 9601) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 396) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Lipid-Anchored | UniProt | By Similarity {ECO:0000250} | Assigned Ontology terms |
Description |
|
|---|---|
| Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). {By Similarity}. | Assigned Ontology terms |
Database | Links |
| UNIPROT | Q5NVI9 |
| Pfam | PF00226 PF01556 PF00684 |
| PROSITE | PS00636 PS50076 PS51188 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory