NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Cytoplasmic FMR1-interacting protein 2 - Pongo abelii - NucEnvDB

Cytoplasmic FMR1-interacting protein 2 (Pongo abelii)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Cytoplasmic FMR1-interacting protein 2
Accession Code	Q5R414
Gene	CYFIP2
Organism	Pongo abelii \| Sumatran orangutan (Taxonomy: 9601)
Part of Reference Proteome?	Yes
Sequence (Length: 1253)
MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQR KAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEK HMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELF DLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDW EGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDH ILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLD QAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANIQPYYLYGSKPLNIAYSHIYSSYRNFVGP PHFKTICRLLGYQGIAVVMEELLKIVESLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGE RLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQ RRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q96F07}. Nucleus {By SimilarityUniProtKB:Q96F07}. Cytoplasm, perinuclear region {ECO:0000250\|UniProtKB:Q5SQX6}. Synapse, synaptosome {ECO:0000250\|UniProtKB:Q5SQX6}. Note=Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). {ECO:0000250\|UniProtKB:Q5SQX6}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Cytoplasm (GO:0005737) Neuron Projection (GO:0043005) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Synapse (GO:0045202)

Biology & Function

Description
Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {By SimilarityUniProtKB:Q5SQX6, By SimilarityUniProtKB:Q96F07}.
Assigned Ontology terms

Biological Process	Apoptotic Process (GO:0006915) Cell-Cell Adhesion (GO:0098609) Regulation Of Actin Filament Polymerization (GO:0030833)
Molecular Function	Small GTPase Binding (GO:0031267)

Cross-References

Database	Links
UNIPROT	Q5R414 Q5R6T9
Pfam	PF07159 PF05994

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