NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

3'-5' RNA helicase YTHDC2 - Pongo abelii - NucEnvDB

3'-5' RNA helicase YTHDC2 (Pongo abelii)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	3'-5' RNA helicase YTHDC2
Accession Code	Q5R746
Gene	YTHDC2
Organism	Pongo abelii \| Sumatran orangutan (Taxonomy: 9601)
Part of Reference Proteome?	Yes
Sequence (Length: 1430)
MSRPSSVSPRQPAPGGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAVRSL IQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERV AAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYT NKEMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPGSQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLVKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFA SQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFA DNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHT KLLAPVNCPVADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKA RSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEM TRAHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFKLEPEAASLLLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQ QPSGIGQRPRPMSSEELPLASSWRSNNSRKSSADTEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRGTEDRSDQSSVKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRN LEISQQKGIWSTTPSNERKLNRAFWESSMVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPQVGEQLLQLWERLPLGEKNTTD

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:B2RR83}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q9H6S0}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Perinuclear Region Of Cytoplasm (GO:0048471) Ribonucleoprotein Granule (GO:0035770)

Biology & Function

Description
3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6- methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis. {By SimilarityUniProtKB:B2RR83}.
Assigned Ontology terms

Biological Process	Germline Cell Cycle Switching, Mitotic To Meiotic Cell Cycle (GO:0051729) Meiotic Cell Cycle (GO:0051321) Oocyte Development (GO:0048599) Spermatid Development (GO:0007286)
Molecular Function	3'-5' RNA Helicase Activity (GO:0034458) ATP Binding (GO:0005524) ATP Hydrolysis Activity (GO:0016887) N6-Methyladenosine-Containing RNA Binding (GO:1990247) RNA Binding (GO:0003723)

Cross-References

Database	Links
UNIPROT	Q5R746 A0A2J8XEL0
Pfam	PF00270 PF04408 PF00271 PF07717 PF01424 PF04146
PROSITE	PS50297 PS50088 PS51192 PS51194 PS51061 PS50882

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