NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Kinesin heavy chain isoform 5A - Pongo abelii - NucEnvDB

Kinesin heavy chain isoform 5A (Pongo abelii)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Kinesin heavy chain isoform 5A
Accession Code	Q5R9K7
Gene	KIF5A
Organism	Pongo abelii \| Sumatran orangutan (Taxonomy: 9601)
Part of Reference Proteome?	Yes
Sequence (Length: 1032)
MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFH IKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSGPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLS ALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEEAALG AELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQQELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELS QKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVERHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSV ELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDL KGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSG KRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNSLFQNYQNLYLQATPSSTSDMYFANSCTGSGATSSGGPLASYQKANMDNGNATDIKDNRSDLPCGYEAEDQAKLFPLHQETAAS

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q6QLM7}. Cytoplasm, cytoskeleton {By SimilarityUniProtKB:Q6QLM7}. Perikaryon {By SimilarityUniProtKB:Q6QLM7}. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region. {By SimilarityUniProtKB:Q6QLM7}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Axon Cytoplasm (GO:1904115) Microtubule (GO:0005874) Perikaryon (GO:0043204) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. {By SimilarityUniProtKB:P33175, By SimilarityUniProtKB:Q6QLM7}.
Assigned Ontology terms

Biological Process	Anterograde Axonal Protein Transport (GO:0099641) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	ATP Binding (GO:0005524) Microtubule Binding (GO:0008017) Microtubule Motor Activity (GO:0003777)

Cross-References

Database	Links
UNIPROT	Q5R9K7
Pfam	PF00225
PROSITE	PS00411 PS50067

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