NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Cyclin-F - Xenopus tropicalis - NucEnvDB

Cyclin-F (Xenopus tropicalis)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Cyclin-F
Accession Code	Q5XGG5
Gene	ccnf
Organism	Xenopus tropicalis \| Tropical clawed frog (Taxonomy: 8364)
Part of Reference Proteome?	Yes
Sequence (Length: 763)
MKGGALHCRCSKCFAAPPKRRVKRRPRVLTLLSLPEDVLLYVLECLPAVDILSMREVHPHLRSLVDSHSSVWARASFQDVWPSPENLNLFERAAECGNFEACVKLGIAYLYNEGLSLSDDGRAEVNGLKA SRFFSLTERLNSGADPFVWLFIRPPWSSSGSCCKAVVFDSLKEECGTVTSEEGATGALKGSIQYCLAKVLSLFEDDDKKREALGMLESSASHGCLHSSYLLWETKQKTALSDPGRYLQSFRQLRDYAARG CWDAQISLAKACGHKNQLSQEQRSASELVNQVFQSSLPINKTSIFTTQKGMNDTMRYILIDWLVEVATMKDFSSLCLHMTVGLVDRYLKLRSVPRAKLQLVGIACMVICTRFISKEILTIREAVWLTDNT YKYEDLVRMMGEIISALEGKIRMPTVVDYKDVLSHLIPLDRSTLHLCSYISELSLLYTELSTYSPAQLAAGALLLARILHKQARPWPAQLAETTGFTLEHLTPCVVLLHKKCFHDDAPKDYRQVSLTAVK QRFQDDLYDQISKEKVMDHSHLCELLGVPCRDSESPASCPNAADFHQFLCSPSGSKTKRRREDSIQEDRGSFVTTPTAELSNQEEDLLGDFLDWSLETSCSGYEGDRESEGEREGEVTAPSGVLDLSLLI TEHQQCQDTTSDDDSLVPLHPIPLLSKLENGTHSTEGCAEKSSGYSSVSSGGSPTSSSSPPGLPFTPTPGLNHSKLMPIPFPQPCSPLFKASRRQVKRKNQAQHSEDNLSDEL

Subcellular Location

Description
Nucleus {By SimilarityUniProtKB:P41002}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P41002}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {By SimilarityUniProtKB:P41002}. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localizes to the nucleus in G2 phase. {By SimilarityUniProtKB:P41002}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Centriole (GO:0005814) Centrosome (GO:0005813) Cyclin-Dependent Protein Kinase Holoenzyme Complex (GO:0000307) Cytoplasm (GO:0005737) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) SCF Ubiquitin Ligase Complex (GO:0019005)

Biology & Function

Description
Substrate recognition component of the SCF(CCNF) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins during G2 phase involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). {By SimilarityUniProtKB:P41002}.
Assigned Ontology terms

Biological Process	Cell Division (GO:0051301) Mitotic Cell Cycle Phase Transition (GO:0044772) Negative Regulation Of Centrosome Duplication (GO:0010826) Protein Ubiquitination (GO:0016567) Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity (GO:0000079) SCF-Dependent Proteasomal Ubiquitin-Dependent Protein Catabolic Process (GO:0031146)
Molecular Function	Cyclin-Dependent Protein Serine/Threonine Kinase Regulator Activity (GO:0016538)

Cross-References

Database	Links
UNIPROT	Q5XGG5
Pfam	PF02984 PF00134 PF00646
PROSITE	PS00292 PS50181

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