National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Palmitoyltransferase ZDHHC20 |
| Accession Code | Q5Y5T1 |
| Gene | Zdhhc20 |
| Organism | Mus musculus | House mouse (Taxonomy: 10090) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 380) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | By Similarity {ECO:0000250|UniProtKB:Q5W0Z9} | Assigned Ontology terms |
Description |
|
|---|---|
| Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:15603741). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains (By similarity). {By SimilarityUniProtKB:Q5W0Z9, Curator InferencePubMed:15603741}. | Assigned Ontology terms |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory