National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Soluble interleukin-15 receptor subunit alpha |
| Accession Code | Q60819 |
| Gene | Il15ra |
| Organism | Mus musculus | House mouse (Taxonomy: 10090) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 263) |
Structure Viewer (PDB: 2PSM) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. |
| Nuclear Membrane | SL-0182 | The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
|
|---|---|
| High-affinity receptor for interleukin-15 (PubMed:17947230). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (PubMed:17947230). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (By similarity). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (By similarity). {By SimilarityUniProtKB:Q13261, Experimental EvidencePubMed:17947230}. | Assigned Ontology terms |
Database | Links |
| UNIPROT | Q60819 A2AP35 A2AP36 A2AP37 Q80Z90 Q80Z91 Q80Z92 Q8R5E4 |
| PDB | 2PSM |
| Pfam | PF00084 |
| PROSITE | PS50923 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory