National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Leukotriene C4 synthase |
| Accession Code | Q60860 |
| Gene | Ltc4s |
| Organism | Mus musculus | House mouse (Taxonomy: 10090) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 150) |
Structure Viewer (PDB: 4NTB) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. |
| Nuclear Membrane | SL-0182 | The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane. |
| Nuclear Outer Membrane | SL-0183 | The outer membrane of the nucleus is the membrane facing the cytoplasm. In mammals, the outer nuclear membrane is continuous in many places with the rough endoplasmic reticulum and is dotted with ribosomes. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | By Similarity {ECO:0000250|UniProtKB:Q16873} | Assigned Ontology terms |
Description |
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|---|---|
| Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:8706658, PubMed:11319240). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy- docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti- inflammatory and proresolving actions (By similarity). {By SimilarityUniProtKB:Q16873, Experimental EvidencePubMed:11319240, Experimental EvidencePubMed:8706658}. | Assigned Ontology terms |
Database | Links |
| UNIPROT | Q60860 Q5SVR7 Q9QVS1 |
| PDB | 4NTA 4NTB 4NTF |
| Pfam | PF01124 |
| PROSITE | PS01297 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory