NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Exocyst complex component 3 - Rattus norvegicus - NucEnvDB

Exocyst complex component 3 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Exocyst complex component 3
Accession Code	Q62825
Gene	Exoc3
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 755)
MCKDSACFSTMKETDLEAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLSQLHNALNDVKDIQQSLADVSKDWRQSINTIESLKDVKDAVVQHSQLAAAVENLKNIF SVPEIVRETQDLIEQGALLQAHRKLMDLECSRDGLMCEQYRMDSGNKRDMTLIHGYFGSTQGLSDELAKQLWMVLQRSLVTVRRDPTLLVSVVRIIEREEKIDRRILDRKKQTGFVPPGRPKNWKEKMFA VLDRTVTTRIEGTQADTRESDKMWLVRHLEIIRKYVLDDLVIAKNLLVQCFPPHYDIFKNLLSMYHQALSIRMQDLASEDLEANEIVSLLTWVLNTYTSAEMMGNVELAPEVDVNALEPLLSPNVVSELL DTYMSTLTSNIIAWLRKALETDKKDWSKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQISEDLKTKVLVLCLQQMNSFLSRYKEEAQLYKEEHLRNRQHPHCYVQYMVAIINNCQTFKESIISLKRK YLKPETEESLCQSQPSMDGILDAIAKEGCSSLLEEVFLDLEQHLNELMTKKWMLGSNAVDIICVTVEDYFNDFAKIKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFRSAEERKEGAEKMVREAEQLRFL FRKLASGFGEDADGHCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLALRGDASRDMKQTIMETLEQGPMQASPNYVPIFQEIVVPSLNVAKLLK

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:12954101}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:12954101}. Cell projection, growth cone {Experimental EvidencePubMed:12954101}. Cell projection, neuron projection {Experimental EvidencePubMed:12954101}. Midbody {ECO:0000250\|UniProtKB:O60645}. Golgi apparatus {ECO:0000250\|UniProtKB:O60645}. Note=Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (PubMed:12954101). During mitosis, early recruitment to the midbody requires RALA, but not RALB, and EXOC2. In late stages of cytokinesis, localization to the midbody is RALB-dependent (By similarity). {ECO:0000250\|UniProtKB:O60645, Experimental EvidencePubMed:12954101}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Exocyst (GO:0000145) Golgi Apparatus (GO:0005794) Growth Cone (GO:0030426) Midbody (GO:0030496) Perinuclear Region Of Cytoplasm (GO:0048471) Presynaptic Membrane (GO:0042734)

Biology & Function

Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Assigned Ontology terms

Biological Process	Exocyst Localization (GO:0051601) Exocytosis (GO:0006887) Protein Transport (GO:0015031)
Molecular Function	SNARE Binding (GO:0000149)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P97879	Glutamate receptor-interacting protein 1 (GRIP-1) (AMPA receptor-interacting protein GRIP1)	EBI-15885274	0.35
P07949	Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]	EBI-22248789	0.35

Cross-References

Database	Links
UNIPROT	Q62825 Q4QQU2
Pfam	PF06046

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