NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Guanylate-binding protein 1 - Rattus norvegicus - NucEnvDB

Guanylate-binding protein 1 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Guanylate-binding protein 1
Accession Code	Q63663
Gene	Gbp2
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 589)
MASEIHMLQPMCLIENTEAHLVINQEALRILSAINQPVVVVAIVGLYRTGKSYLMNKLAGKRTGFSLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEGLEDVEKGDNQNDCWIFALAVLLSSTFVYNS MGTINQQAMDQLHYVTELTDLIKSKSSPDQSGIDDSANFVGFFPTFVWALRDFSLELEVNGKLVTPDEYLEHSLTLKKGADKKTKSFNEPRLCIRKFFPKRKCFIFDRPALRKQLCKLETLGEEELCSEF VEQVAEFTSYIFSYSAVKTLSGGIIVNGPRLKSLVQTYVGAISSGSLPCMESAVLTLAQIENSAAVQKAITHYEEQMNQKIQMPTETLQELLDLHRLIEREAIEIFLKNSFKDVDQKFQTELGNLLISKR DAFIKKNSDVSSAHCSDLIEDIFGPLEEEVKQGTFSKPGGYFLFLQMRQELEKKYNQAPGKGLEAEAVLKKYFESKEDIVETLLKTDQSLTEAAKEIEVERIKAETAEAANRELAEKQEKFELMMQQKEE SYQEHVRQLTEKMKEEQKKLIEEQDNIIALKLREQEKFLREGYENESKKLLREIENMKRRQSPGKCTIL

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:P32456}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P32456}. Golgi apparatus membrane {By SimilarityUniProtKB:P32456}. Membrane {By SimilarityUniProtKB:P32456}; Lipid-anchor {By SimilarityUniProtKB:P32456}. Cytoplasmic vesicle {ECO:0000250\|UniProtKB:Q9Z0E6}. Note=GBP2-GBP5 dimers localize to the Golgi apparatus. {By SimilarityUniProtKB:P32456}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	Experimental Evidence {ECO:0000269\|PubMed:8148370}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytoplasmic Vesicle (GO:0031410) Golgi Apparatus (GO:0005794) Golgi Membrane (GO:0000139) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). {By SimilarityUniProtKB:P32455, By SimilarityUniProtKB:P32456, By SimilarityUniProtKB:Q9Z0E6}.
Assigned Ontology terms

Biological Process	Adhesion Of Symbiont To Host (GO:0044406) Cellular Response To Interferon-Beta (GO:0035458) Cellular Response To Type II Interferon (GO:0071346) Cellular Response To Interleukin-1 (GO:0071347) Cellular Response To Lipopolysaccharide (GO:0071222) Cellular Response To Tumor Necrosis Factor (GO:0071356) Defense Response To Gram-Positive Bacterium (GO:0050830) Defense Response To Protozoan (GO:0042832) Protein Localization To Nucleus (GO:0034504) Response To Bacterium (GO:0009617)
Molecular Function	GTP Binding (GO:0005525) GTPase Activity (GO:0003924) Identical Protein Binding (GO:0042802) Protein Homodimerization Activity (GO:0042803)

Cross-References

Database	Links
UNIPROT	Q63663
Pfam	PF02263 PF02841
PROSITE	PS51715

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK